Results 151 to 160 of about 7,089,436 (312)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

A world model, a model world [PDF]

open access: yesEnvironmental Toxicology and Chemistry, 2004
Frank A P C, Gobas, Derek C G, Muir
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Retracted: Regenerative Medicine for Neurological Disorders

open access: yesThe Scientific World Journal, 2012
The Scientific World Journal
doaj   +1 more source

Corrigendum to “Biosmart Materials: Breaking New Ground in Dentistry”

open access: yesThe Scientific World Journal, 2020
The Scientific World Journal
doaj   +1 more source

Predicting long-term poor outcomes in individuals at clinical high risk for psychosis using real-world clinical data: the OASIS1000 prospective study. [PDF]

open access: yesWorld Psychiatry
Logeswaran Y   +10 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

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