Results 91 to 100 of about 1,384,315 (209)

Workplace Learning: Main Themes & Perspectives [PDF]

This paper provides an overview and critical discussion of some of the main themes and perspectives within existing academic literature concerning workplace learning.
Lee, Tracey, Felstead, Alan, Fuller,, Alison, Ashton, David, Unwin, Lorna, Walters, Sally, Butler, Peter   +6 more
core   +1 more source

Definitions of Person-Centeredness for Persons With Dementia in the United States: A Scoping Review. [PDF]

J Appl Gerontol
Efird-Green L, Jones LB, Fazio S, Zimmerman S.   +3 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Navigating ICU Survival With a Temporary Tracheostomy. A Phenomenological Hermeneutic Study. [PDF]

Scand J Caring Sci
Akroute A, Brinchmann BS, Hovland A, Fredriksen STD.   +3 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Regulatory Readiness for Paper Replacement in Global Pharmaceutical Electronic Labeling: Cross-Sectional Comparative Policy Analysis. [PDF]

J Med Internet Res
Lee DE, Chun JS, Kim M, Kim IW, Oh JM.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Research Trends and Hot Topics in Nursing Research on Children with Disabilities: A Bibliometric Analysis from 1977 to 2026. [PDF]

Healthcare (Basel)
Ozcelik H, Şenol Ş, Avci HH.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Lessons Learned in the Early Adoption of FaME Across Ireland: A Convergent Mixed-Methods Implementation Study (FaME Ireland). [PDF]

Health Expect
Rooney S, Ahern L, Brennan E, Cahalane E, Cummins V, Eldridge C, Horgan F, Skelton DA, Shé ÉN, Thackeray K, Vig B, McCullagh R.   +11 more
europepmc   +1 more source