Results 41 to 50 of about 34,208 (235)

mouseTube – a database to collaboratively unravel mouse ultrasonic communication [version 1; referees: 2 approved]

F1000Research, 2016
Ultrasonic vocalisation is a broadly used proxy to evaluate social communication in mouse models of neuropsychiatric disorders. The efficacy and robustness of testing these models suffer from limited knowledge of the structure and functions of these ...
Nicolas Torquet, Fabrice de Chaumont, Philippe Faure, Thomas Bourgeron, Elodie Ey   +4 more
doaj   +1 more source

Cognition Without Neural Representation: Dynamics of a Complex System

Frontiers in Psychology, 2022
This paper proposes an account of neurocognitive activity without leveraging the notion of neural representation. Neural representation is a concept that results from assuming that the properties of the models used in computational cognitive neuroscience
Inês Hipólito
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization

Nature Communications, 2022
The intrinsic dynamics of neurons, in particular the generation action potentials, can impact neural network states and processes of encoding information.
Janina Hesse, Jan-Hendrik Schleimer, Nikolaus Maier, Dietmar Schmitz, Susanne Schreiber   +4 more
doaj   +1 more source

Context-sensitive computational mechanistic explanation in cognitive neuroscience

Frontiers in Psychology, 2022
Mainstream cognitive neuroscience aims to build mechanistic explanations of behavior by mapping abilities described at the organismal level via the subpersonal level of computation onto specific brain networks.
Matthieu M. de Wit, Heath E. Matheson
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Interrogating theoretical models of neural computation with emergent property inference

eLife, 2021
A cornerstone of theoretical neuroscience is the circuit model: a system of equations that captures a hypothesized neural mechanism. Such models are valuable when they give rise to an experimentally observed phenomenon -- whether behavioral or a pattern ...
Sean R Bittner, Agostina Palmigiano, Alex T Piet, Chunyu A Duan, Carlos D Brody, Kenneth D Miller, John Cunningham   +6 more
doaj   +1 more source

An Integrated Five-Discipline Computational Framework for Modeling Neurochemical Dysfunction in Symptomatic Rabies: A Rigorous Theoretical Protocol Combining Computational Neuroscience, Mathematical Virology, Systems Biology, Bayesian Inference, and Neuropharmacology

Sami Rashid Mohammed Shibah
  +6 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source