Results 91 to 100 of about 2,279,863 (316)

Analysis of macaque BTN3A genes and transcripts in the extended MHC: conserved orthologs of human γδ T cell modulators

, 2019
Butyrophilins (BTN), specifically BTN3A, play a central role in the modulation of γδ T cells, which are mainly present in gut and mucosal tissues. BTN3A1 is known, for example, to activate Vγ9Vδ2 T cells by means of a phosphoantigen interaction.
de Groot, Natasja G., Groen, Rens, Orie, Vaneesha, Doxiadis, Gaby G.M., Sub Theoretical Biology, de Groot, Nanine, Bruijnesteijn, Jesse, Bontrop, Ronald E., Theoretical Biology and Bioinformatics   +8 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

A theoretical analysis of the dissociation of OH radical: Fine-structure distributions of the O(3PJ) product

, 2011
A theoretical analysis of the dissociation of OH radical: Fine-structure distributions of the O(3PJ ...
张佩宇, 李元俊
core  

Curriculum planning with 'learning outcomes': a theoretical analysis [PDF]

, 2007
The use of learning outcomes for curriculum planning is widely advocated in higher education, it is supported by an imposing set of claims, and it has official sanction, for example from the Quality Assurance Agency (QAA). In opposition, there are fierce
Kemp, Brian
core  

Specificity of inhibitory KIRs enables NK cells to detect changes in an altered peptide environment

, 2018
The activity of natural killer (NK) cells is tightly regulated by inhibitory and activating receptors. Inhibitory killer immunoglobulin-like receptors (iKIRs) survey the surface of target cells by monitoring the expression of human leukocyte antigen (HLA)
de Boer, Rob J, Kesmir, Can, Sub Theoretical Biology, Carrillo-Bustamante, Paola, Theoretical Biology and Bioinformatics   +4 more
core   +1 more source

Research on Seabed Erosion Monitoring Technology of Offshore Structures Based on the Principle of Heat Transfer

Applied Sciences
The erosion of the seabed around offshore structures has emerged as a critical factor impeding the operational safety of offshore engineering facilities.
Jilong Yin, Huaqing Zhang, Mengmeng Liu, Yichu Li   +3 more
doaj   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Collective effects of link failures in linear flow networks

New Journal of Physics, 2020
The reliable operation of supply networks is crucial for the proper functioning of many systems, ranging from biological organisms such as the human blood transport system or plant leaves to man-made systems such as power grids or gas pipelines.
Franz Kaiser, Julius Strake, Dirk Witthaut   +2 more
doaj   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Dynamics driven by the trace anomaly in FLRW universes

, 2009
By means of a semiclassical analysis we show that the trace anomaly does not affect the cosmological constant. We calculate the evolution of the Hubble parameter in quasi de Sitter spacetime, where the Hubble parameter varies slowly in time, and in FLRW ...
Sub Algemeen Theoretical Physics, Theoretical Physics, Koksma, J.F.   +2 more
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