Results 31 to 40 of about 102,004 (259)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Multipole analysis for linearized $$f(R,{\mathcal {G}})$$ f(R,G) gravity with irreducible Cartesian tensors

open access: yesEuropean Physical Journal C: Particles and Fields, 2019
The field equations of $$f(R,{\mathcal {G}})$$ f(R,G) gravity are rewritten in the form of obvious wave equations with the stress–energy pseudotensor of the matter fields and the gravitational field as its source under the de Donder condition.
Bofeng Wu, Chao-Guang Huang
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Solving the Bars-Green equation for moving mesons in two-dimensional QCD

open access: yesJournal of High Energy Physics, 2017
The two-dimensional QCD in the large N limit, generally referred to as the ’t Hooft model, is numerically investigated in the axial gauge in a comprehensive manner.
Yu Jia   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Amplitude/operator basis in chiral perturbation theory

open access: yesJournal of High Energy Physics, 2023
We establish a systematic construction of the on-shell amplitude/operator basis for Chiral Perturbation Theory (ChPT) in D = 4 spacetime dimensions and with an arbitrary number of flavors N f .
Ian Low   +3 more
doaj   +1 more source

An Experimental and Theoretical High Energy Physics Program [PDF]

open access: yes, 2012
The Purdue High Energy Physics Group conducts research in experimental and theoretical elementary particle physics and experimental high energy astrophysics. Our goals, which we share with high energy physics colleagues around the world, are to understand at the most fundamental level the nature of matter, energy, space and time, and in order to ...
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Primordial gravitational waves assisted by cosmological scalar perturbations

open access: yesEuropean Physical Journal C: Particles and Fields
Primordial gravitational waves are a crucial prediction of inflation theory, and their detection through their imprints on the cosmic microwave background is actively being pursued. However, these attempts have not yet been successful.
Yan-Heng Yu, Sai Wang
doaj   +1 more source

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