Results 91 to 100 of about 5,929,152 (343)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Assessing authenticity in modelling test items: deriving a theoretical model

Frontiers in Education
Authenticity is considered a central feature in the context of teaching and learning mathematical modelling and is often demanded for both learning tasks and test items.
Dominik Schlüter, Michael Besser
doaj   +1 more source

Evaluating an integrated primary care approach to improve well-being among frail community-living older people: A theory-guided study protocol

BMC Geriatrics, 2018
Background A major challenge in primary healthcare is the substantial increase in the proportion of frail community-dwelling older persons with long-term conditions and multiple complex needs.
Lotte Vestjens, Jane M. Cramm, Erwin Birnie, Anna P. Nieboer   +3 more
doaj   +1 more source

On the determination of step energies. Theoretical considerations and application to an anisotropic Kossel model [PDF]

, 2006
M. A. Deij, J. Los, Hugo Meekes, Elias Vlieg   +3 more
openalex   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Theoretical evaluation of round-trip efficiency of solid gravity energy storage systems

Journal of Intelligent Construction
Solid gravity energy storage (SGES) is a method of energy storage technology that combines the prospects of operation safety, cost-effectiveness, and adaptive application.
Zhiyan Lin, Zichang Li, Peng Lin, Zicheng Zhong, Lin Chai   +4 more
doaj   +1 more source

THEORETICAL ASPECTS OF QUINTOM MODELS [PDF]

Modern Physics Letters A, 2010
Quintom models, with its Equation of State being able to cross the cosmological constant boundary w = -1, turns out to be attractive for phenomenological study. It can not only be applicable for dark energy model for current universe, but also lead to a bounce scenario in the early universe.
openaire   +2 more sources

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran, Malo Gaubert, Alice Dufey, Elise Bannier, Audrey Rico, Jean‐Christophe Ferré, Raphaël Chouteau, Laure Michel, Emmanuelle Le Page, Virginie Callot, Bertrand Audoin, Sarah Demortière, Benoît Combès, Anne Kerbrat   +13 more
wiley   +1 more source

ANALYSIS OF MARKET EFFICIENCY OF THE ORGANIZATION OF SERVICES FOR PATIENTS WITH LONGSTANDING AND PERMANENT FORMS OF ATRIAL FIBRILLATION BASED ON THEORETICAL MODEL

Клінічна та профілактична медицина
Introduction. Rational consumption of medical services requires consideration of several key factors: cost, quality, comfort, and the level of patient awareness.
Anastasiia A. Rudenko, Oleksandr M. Ocheredko, Iryna V. Iaremyna, Olena V. Tkachenko   +3 more
doaj   +1 more source