Results 51 to 60 of about 5,813,746 (293)

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Trust Exploitation and Attention Competition: A Game Theoretical Model

open access: yes, 2016
The proliferation of Social Network Sites (SNSs) has greatly reformed the way of information dissemination, but also provided a new venue for hosts with impure motivations to disseminate malicious information.
Fu, Hao   +4 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A tourism inflex: Generation Z travel experiences [PDF]

open access: yesJournal of Tourism Futures, 2019
Purpose - The purpose of this paper is twofold. First, it highlights the emergence of Generation Z and the interface of its members with the tourism system.
Victor Mueke Robinson   +1 more
doaj   +1 more source

A one-dimensional model for theoretical analysis of single molecule experiments

open access: yes, 2006
In this paper we compare two polymer stretching experiments. The outcome of both experiments is a force-extension relation. We use a one-dimensional model to show that in general the two quantities are not equal.
Bustamante C   +9 more
core   +1 more source

THEORETICAL MODELS OF DARK ENERGY [PDF]

open access: yesInternational Journal of Modern Physics D, 2012
Mounting observational data confirm that about 73% of the energy density consists of dark energy which is responsible for the current accelerated expansion of the Universe. We present observational evidences and dark energy projects. We then review various theoretical ideas that have been proposed to explain the origin of dark energy; they contain the ...
Yoo, Jaewon, Watanabe, Yuki
openaire   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Rheological Behavior of Gassy Marine Clay: Coupling Effects of Bubbles and Salinity

open access: yesJournal of Marine Science and Engineering
Understanding the rheological behavior of marine clay is crucial to analyzing submarine landslides and their impact on marine resource exploitation. Dispersed bubbles in marine clay (gassy clay) and electrolytes in seawater (e.g., NaCl concentration of 0.
Zhuanzhuan Zhang   +5 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

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