Results 161 to 170 of about 77,712 (368)

Advanced Microfluidics for Single Cell‐Based Cancer Research

open access: yesAdvanced Science, EarlyView.
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro   +10 more
wiley   +1 more source

Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation of Liquid–Liquid Phase Separation in Caenorhabditis elegans

open access: yesAdvanced Science, EarlyView.
Polyhalogenated carbazoles (PHCZ), persistent environmental contaminants, preferentially accumulate in neuronal tissues. Studies using Caenorhabditis elegans and human neuronal cell lines reveal that PHCZ induce dopaminergic neurodegeneration by promoting liquid–liquid phase separation of α‐synuclein, reducing condensate fluidity, impairing ...
Yuhang Luo   +13 more
wiley   +1 more source

A modular SU (5) littlest seesaw

open access: yesJournal of High Energy Physics
We extend the littlest modular seesaw to a Grand Unified scenario based on SU (5) endowed with three modular S 4 symmetries. We leverage symmetry protected zeroes in the leptonic and down quark sectors to suppress deviations to the littlest modular ...
Ivo de Medeiros Varzielas   +2 more
doaj   +1 more source

Flavour in Higgs physics: Theory overview

open access: yes, 2019
Flavour in Higgs physics: Theory ...
openaire   +1 more source

Single‐Cell Transcriptome Analysis Reveals That Hmga2 Regulates Neuroinflammation and Retinal Function by Modulating Müller Cell Autophagy Through PI3K/AKT Signaling Following MCAO‐Induced Retinal Ischemia

open access: yesAdvanced Science, EarlyView.
Employing snRNA‐seq post‐MCAO‐induced retinal ischemia (RI), this study revealed a novel Hmga2‐high Müller cell subpopulation. Hmga2 knockout alleviated neuroinflammation and RI symptoms, potentially by binding PI3K and regulating Müller cell autophagy.
Weihao Lv   +11 more
wiley   +1 more source

The basis invariant flavor puzzle

open access: yesJournal of High Energy Physics
The flavor puzzle of the Standard Model quark sector is formulated in a non-perturbative way, using basis invariants that are independent of the choice of quark field basis.
Miguel P. Bento   +2 more
doaj   +1 more source

A Replicable and Generalizable Neuroimaging‐Based Indicator of Pain Sensitivity Across Individuals

open access: yesAdvanced Science, EarlyView.
Humans differ in their sensitivity to pain. With six large and diverse fMRI datasets (total N = 1046), this study finds that such individual differences in pain sensitivity can be tracked by fMRI responses to painful stimuli. A highly generalizable machine learning model is further built to predict pain sensitivity across all datasets and analgesic ...
Li‐Bo Zhang   +7 more
wiley   +1 more source

Modular symmetry with weighton

open access: yesJournal of High Energy Physics
We systematically develop the weighton mechanism for natural quark and charged lepton mass hierarchies in the framework of modular symmetry with a single modulus field τ.
Gui-Jun Ding   +3 more
doaj   +1 more source

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