MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Advertisement: The Philosophical Journal (Filosofický časopis) 2020/4
Teorie vědy, 2020 Teorie vědy / Theory of Science
doaj
The adventure of a hospitalization: Bringing the reversal theory to the world of design
, 2013 The design & emotion research domain has produced a rich palette of theoretical and methodological approaches that support designers in their attempts to ‘design for emotion’.
Desmet, P.M.A. (author) +2 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Understanding midwifery workforce recruitment and retention: a realist review protocol for synthesising international evidence to inform UK workforce strategy. [PDF]
BMJ OpenStelling H +9 more
europepmc +1 more source
Att skapa ett mer inkluderande utbildningssystem. En avslutande reflektion
Utbildning & Demokrati, 2021 Claes Nilholm
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Quaternionic Superconformal Field Theory
, 1992 We develop a superfield formalism for N=4 superconformal two-dimensional field theory. A list is presented of minimal free superfields, i.e. of multiplets containing four bosons and four fermions.
Quaternionic Superconformal +3 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Boundaries and Bridges: The Complex Alliance Between Counselling and Learning Theories. [PDF]
Integr Psychol Behav SciBorbély-Pecze TB, McCarthy J.
europepmc +1 more source