Results 51 to 60 of about 269,986 (219)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Disappearance of dimits shift in realistic fusion reactor plasmas with negative magnetic shear

Nuclear Fusion
This study employs gyrokinetic simulations to investigate ion temperature gradient (ITG) turbulence in realistic fusion reactor plasmas featuring reversed magnetic shear.
Dingkun Yang, Shengming Li, Yong Xiao, Zhihong Lin   +3 more
doaj   +1 more source

Toward the Uniform of Chemical Theory, Simulation, and Experiments in Metaverse Technology. [PDF]

Precis Chem, 2023
Zhu X.
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Extraordinary transmission of intense short laser pulse through thin foil with near- and sub-wavelength slits

AIP Advances
To supplement our earlier study [Lu et al., AIP Adv. 10, 015209 (2020)] on the propagation of intense short laser pulse through foils with multiple sub-wavelength sized slits, here, we consider the effects of the interaction parameters on the occurrence ...
Sidailuo Lu, Xiaohai Zhang, Zhengmao Sheng, Ming-Young Yu   +3 more
doaj   +1 more source

Understanding DNA Under Oxidative Stress and Sensitization: The Role of Molecular Modeling

Frontiers in Chemistry, 2015
DNA is constantly exposed to damaging threats coming from oxidative stress, i.e. from the presence of free radicals and reactive oxygen species. Sensitization from exogenous and endogenous compounds that strongly enhance the frequency of light-induced ...
Antonio eMonari, Elise eDumont
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reduced kinetic model for ion temperature gradient instability in tokamaks with reversed magnetic shear

Nuclear Fusion
Using the averaged magnetic drift model and a first-order finite Larmor radius expansion, the eigenvalue equation for the ion temperature gradient (ITG) mode in tokamak plasmas is reduced to a Schrödinger-type differential equation.
B. Jia, Q. Zhong, Y. Li, Y. Xiao
doaj   +1 more source