Results 91 to 100 of about 1,295,808 (298)
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
A computer architecture for intelligent machines [PDF]
The Theory of Intelligent Machines proposes a hierarchical organization for the functions of an autonomous robot based on the Principle of Increasing Precision With Decreasing Intelligence.
Lefebvre, D. R., Saridis, G. N.
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FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Nonclassical assembly pathways of anisotropic particles
, 2010 Advances in synthetic methods have spawned an array of nanoparticles and bio-inspired molecules of diverse shapes and interaction geometries. Recent experiments indicate that such anisotropic particles exhibit a variety of 'nonclassical' self-assembly ...
Whitelam, Stephen
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Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
The Human Condition in the 21st Century: Body and Architectural Space in Contemporary Art
Bodrum Journal of Art and DesignArchitectural practices that sustain economic power structures often overlook the complexity of place, prioritizing rationality and utility for funding while perpetuating issues like climate crises and income inequality.
Cansu Sözer, Can Boyacıoğlu
doaj +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Public Leisure Architecture in Colombia, or the Governance of Free Time, 1934–2021
DearqFrom "exclusive luxury" to "labor right," and from a space for amusement to one for disconnection, public leisure architecture in Colombia reflects a shift toward democratizing a practice once reserved for elites—now recognized as an indicator of quality
William García Ramírez
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Three-layered perceptron that is able to learn [PDF]
, 2014 Впервые предложена нейросетевая архитектура и алгоритмы функционирования трехслойного перцептрона, способного дообучаться без потерь запомненной ранее информации.
Бречко, В. А. +2 more
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To the project of architectural theory
проект байкал, 2023 The existence of a general architectural theory is seriously doubted by most researchers. Based on the assumption that the modern stage of architecture development requires the construction of a workable theory, the article considers the process of creating a theory similar to the creation of an architectural project.
openaire +2 more sources