Results 11 to 20 of about 175 (174)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Generic Techniques for Source-Level Debugging and Dynamic Program Slicing
, 1994 Algebraic specifications have been used successfully as a formal basis for software development. The contribution of this paper is to show that the origin and dynamic dependence relations that are implicitly defined by an algebraic specification can be ...
Tip, Frank, Tip, F. (Frank), Frank Tip
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Search based software engineering: Trends, techniques and applications [PDF]
, 2012 © ACM, 2012. This is the author's version of the work. It is posted here by permission of ACM for your personal use. Not for redistribution. The definitive version is available from the link below.In the past five years there has been a dramatic increase
Harman, M, Mansouri, SA, Zhang, Y
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MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Practical Reflection and Metaprogramming for Dependent Types [PDF]
, 2016 Embedded domain-specific languages are special-purpose programming languages that are implemented within existing generalpurpose programming languages.
Christiansen, David Raymond
core +1 more source
Typed Self-Applicable Meta-Programming [PDF]
, 2017 Self-applicable meta-programming has its roots in the early days ofcomputer science.Two early examples were published in 1936: the universal Turingmachine, and a self-interpreter for the λ-calculus.These were major advances in computability theory ...
Brown, Matt
core
On the Importance of Reverse Polish Notation for the Development of Computer Science
, 2020 Artykuł dotyczy wpływu beznawiasowej notacji polskiej na rozwój współczesnej informatyki i innych, pokrewnych dyscyplin naukowych korzystających z technik informatycznych, m.in. matematyki, elektroniki, automatyki czy robotyki.
Gryś, Sławomir, Minkina, Waldemar
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Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source