Results 41 to 50 of about 128,899 (358)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Leg dominance influences side-specific directional movement demands during change-of-direction movements in elite youth soccer players

Frontiers in Sports and Active Living
IntroductionMonitoring training load in youth soccer is a key component of athlete development. However, limited evidence exists regarding the influence of leg dominance on side-specific directional movement demands during change-of-direction movements ...
Krisztián Havanecz, Gábor Géczi, Ádám Hegedüs, János Matlák, Marcell Fridvalszki, Csaba Bartha, Sándor Sáfár, István Csáki, Péter János Tóth, Bence Kopper   +9 more
doaj   +1 more source

Advances in the theory of large cooperative games and application to club theory: the side payments case [PDF]

, 2002
In a series of papers (Kovalenkov and Wooders 2001a, Games and Economic Behavior, 2001b, Mathematics of Operations Research, and 1997, Journal of Economic Theory to appear), the authors have developed the framework of parameterized collections of games ...
Wooders, Myrna Holtz, Kovalenkov, Alexander   +1 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

External training load and rating of perceived exertion comparison between different playing styles and winning vs. losing matches in elite tennis

Frontiers in Sports and Active Living
IntroductionThis study aims to compare different playing styles on external training load and rating of perceived exertion (RPE) in elite Hungarian junior tennis players during the off-season in winning vs. losing matches.MethodsSixteen elite male junior
Péter János Tóth, Péter János Tóth, István Csáki, János Négyesi, János Négyesi, János Négyesi, Károly Dobos, Krisztián Havanecz, Krisztián Havanecz, Sándor Sáfár, Csaba Ökrös   +10 more
doaj   +1 more source

COLLECTIVE CRIBBING: MODEL OF PLAYERS' BEHAVIOUR IN TEAM

Вестник Российского экономического университета имени Г. В. Плеханова, 2017
During one's life a person keeps on facing a dilemma: to attain a set goal by himself or to use team's assistance to make a task easier. A vivid example showing a complexity of choice in similar situation is a process of studying in university, when a ...
Mariya V. Kulabukhova, Olga A. Sokolova
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Economic Harmony—A Rational Theory of Fairness and Cooperation in Strategic Interactions

Games, 2022
Experimental studies show that the Nash equilibrium and its refinements are poor predictors of behavior in non-cooperative strategic games. Cooperation models, such as ERC and inequality aversion, yield superior predictions compared to the standard game ...
Ramzi Suleiman
doaj   +1 more source

Game Theory and Evolution [PDF]

IEEE Intelligent Systems, 2013
Key concepts are described from the area now known as evolutionary game theory, while also introducing some important applications of these concepts.
Steve Phelps, Michael J. Wooldridge
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source