Results 71 to 80 of about 115,024 (305)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Affective Equality as a Key Issue of Justice : A Comment on Fraser’s 3-Dimensional Framework

, 2013
The relational realities of nurturing constitute a discrete site of social practice within and through which inequalities are created. The affective worlds of love, care and solidarity are therefore sites of political import that need to be examined in ...
Lynch, Kathleen
core  

The Theory of Justice and Ultra petita Decisions: A Critical Analysis of Judicial Review in the Constitutional Court

Constitutionale
Under Law Number 24 of 2003, the Constitutional Court of Indonesia issues three types of decisions: inadmissibility, acceptance, and rejection. Over time, the Court introduced additional categories, including conditional constitutional and conditional ...
Eza Tri Yandy, Tri Endah Karya Lestiyani   +1 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Role of justice theory in explaining alliance negotiations, The [PDF]

We report data from a revelatory qualitative case study of a failed attempt to negotiate an international joint venture agreement. We analyze issues of justice and the role that their occurrence in the course of the negotiations might have played in this
Ariño, Africa, Ring, Peter S.
core  

Health and justice: the capability to be healthy.

, 2010
This is an inter-disciplinary argument for a moral entitlement to a capability to be healthy. Motivated by the goal to make a human right to health intelligible and justifiable, the thesis extends the capability approach, advocated by Amartya Sen and ...

core   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

A Theory of Justice [PDF]

The University of Toronto Law Journal, 1973
D. P. Dryer, John Rawls
  +6 more sources

CRITIQUE OF LIBERAL-DEMOCRATIC REASON. RAWLS’S DEONTOLOGICAL THEORY WITH REGARD TO THE PROBLEM OF REFUGEE’S POLITICAL INTEGRATION

Sovremennye Issledovaniâ Socialʹnyh Problem, 2019
Purpose. The article is devoted to normative constraints of deontological theory with regard to the problem of refugee’s political integration. The subject of the analysis is Rawls’s theory of justice.
Konstantin Valeryevich Fomin
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source