Results 121 to 130 of about 173,752,047 (299)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Comparing prediction power of exercise intention and behavior based on self-efficacy and theory of planned behavior

open access: yesPayesh, 2013
Objective (s): To compare prediction power of exercise intention and behavior based on self-efficacy and theory of planned behavior.Methods: This cross-sectional study was conducted in the kahrizak Nursing home in Tehran.
Leila Ghahremani, Mahin Nazari
doaj  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Measuring a cash waqf giving behavior among Muslim donor in Malaysia: a theory of planned behavior approach using structural equation modeling

open access: yes, 2017
This study investigated cash waqf giving behavior among Muslim donors based on the Theory of Planned Behavior. A survey was conducted on 370 Muslim donors working in government and private agencies/institutions located in Selangor Darul Ehsan, Malaysia ...
Mohammed, Mustafa Omar   +1 more
core  

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Using the planned behavior theory to model job search behavior among Chinese unemployed

open access: yes, 2004
Job search is an important part in people’s career. The current study surveyed 99 job seekers in China to test a job search model based on the theory of planned behavior.
Z. L. Song, X. Y. Niu, K. Shi, Y. Z. Xie
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Assessment of Factors Associated With Hookah Consumption Among College Students of Asad Abad City Base on The Theory of Planned Behavior (TPB) in 2015-2016.

open access: yesآموزش بهداشت و ارتقاء سلامت ایران, 2017
Background and Objective: The Tobacco use is recognized as a global health problem. Considering the high prevalence of hookah consumption among college students and its risks and negative consequences on the human health, this study aimed to investigate ...
Zeinab Makvandi   +2 more
doaj  

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