Results 61 to 70 of about 30,993 (216)

Understanding Teachers’ Intention and Behaviour Towards Inclusive Education in Ghana: Applying the Theory of Planned Behaviour

Education Sciences
United Nations Sustainable Development Goal 4 advocates for equitable access to and participation in quality inclusive education for all learners. Inclusive education has gained worldwide recognition for promoting equity and social justice for students ...
Michael Amponteng, Danielle Tracey, William Nketsia   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Predicting Malaysian household food waste behaviour through an integrated framework of theory of planned behaviour (TPB) and theory of interpersonal behaviour (TIB)

Discover Food
Food waste by households is increasing rapidly in developing countries like Malaysia, contributing to environmental damage, higher food costs and threaten reliable food supply.
Ah-Suat Lee, Nurul Afidah Mohamad Yusof, Saw-Chin Khor, Yen-Hong Ng, Suet-Ling Ching, Lin-Sea Lau, Muhammad Rizky Prima Sakti   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Social factors influencing waste separation behaviour among the multi-class residents in a megacity: A Survey analysis from a community in Bangkok, Thailand

Sustainable Futures
Effective waste separation at the source is vital for sustainable waste management globally. However, motivating people to participate in waste separation can be challenging, especially in developing countries' megacities, where rapid urbanization and ...
Unruan Leknoi, Annop Yiengthaisong, Suched Likitlersuang   +2 more
doaj   +1 more source

The manager’s decision in acknowledging and disclosing environmental liability: A Behavioral Model

Journal of Economics, Business & Accountancy Ventura, 2016
This study analyzes why managers accrue and disclose environmental liability, which involves managers’ discretions. Using the framework of the Theory of Planned Behavior (Ajzen 1991), this research hypothesizes that a manager’s intention to accrue and ...
Susi Sarumpaet
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The effect of an educational intervention in prevention of drug abuse in students

International Journal of Adolescence and Youth
The present study is a quasi-experimental intervention research conducted on 300 adolescent boys aged 14–19 in Jahrom city, Iran, in 2022. Data collection tools included a demographic information questionnaire, a knowledge questionnaire, and constructs ...
Tayebeh Rakhshani, Sajedeh Kamranpoor, Amirhossein Kamyab, Asiyeh Yari, Ali Khani Jeihooni   +4 more
doaj   +1 more source