Results 41 to 50 of about 1,879,596 (394)

The Meaning of Distributive Justice for Aristotle’s Theory of Constitutions [PDF]

open access: yes, 2016
: This paper examines Aristotle’s theory of distributive justice and its meaning for his theory of constitutions. First, it shows that his account of constitutions in Books IV–VI of the Politics is an extension and refinement of his scheme of six ...
Dr Knoll, Manuel
core   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

Theory of Politics in Poland on the Track of Consensual Approaches to “the Political”

open access: yesTeoria Polityki, 2023
Polish political theorists’ research revolves around the question of the political. There have been many analyses of this issue in Polish political science journals, for which the starting point was ...
Łukasz Młyńczyk
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

The vanishing boundaries between technical and political: normativism and pragmatism in the Brazilian courts’ adjustment of public policies

open access: yesRevista de Investigações Constitucionais, 2015
In law, normativism and pragmatism have always been under tension and this has been revealed in many different ways. One of its manifestations can be found in adjudication, where the technical/juridical role of the judge has, in many countries, assumed ...
Juliana Pondé Fonseca
doaj   +1 more source

In Which Sense, If Any, Is Educational Theory ‘Political’? A Pragmatist Perspective

open access: yesTeoría de la Educación: Revista Interuniversitaria, 2023
This paper tackles the question of in which sense, if any, educational theory should be considered as ‘political’. From a pragmatist perspective it evaluates three meanings of the term: first, the political as an exception, such as Rancière’s ...
Kai Wortmann
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Long waves of political contestation [PDF]

open access: yes, 2015
This paper develops a wave theory of political contestation, and places the current economic and political turmoil in a historical perspective. Based on legitimacy, it serves as an alternative to the waves of democratization of Samuel Huntington (1991 ...
Van Vossole, Jonas
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Challenges with Studying Islamist Groups in American Political Science

open access: yesAmerican Journal of Islam and Society, 2023
In this paper, I will explain why the lack of debate between political theory and comparative politics has led to an inadequate understanding of the politics of traditional Islamic scholars and Islamists in American political science.
Tabinda Mahfooz Khan
doaj   +1 more source

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