Results 41 to 50 of about 202,848,213 (302)

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

open access: yesMolecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi   +2 more
wiley   +1 more source

Anti-politics in context: the politics of localism in London [PDF]

open access: yes, 2017
There is a substantial body of theory on the notion of anti-politics, which is characterised as a widespread public disengagement from politics. The Localism Act 2011 was intended to increase engagement. This paper reviews research into the development
Pycock, G.
core  

A Theory of Political Entrenchment [PDF]

open access: yesThe Economic Journal, 2012
We develop a theory of endogenous political entrenchment in a simple two-party dynamic model of income redistribution with probabilistic voting. A partially self-interested left-wing party may implement (entrenchment) policies reducing the income of its own constituency, the lower class, in order to consolidate its future political power. Such policies
Gilles Saint-Paul   +2 more
openaire   +16 more sources

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

open access: yesFEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph   +7 more
wiley   +1 more source

The vanishing boundaries between technical and political: normativism and pragmatism in the Brazilian courts’ adjustment of public policies

open access: yesRevista de Investigações Constitucionais, 2015
In law, normativism and pragmatism have always been under tension and this has been revealed in many different ways. One of its manifestations can be found in adjudication, where the technical/juridical role of the judge has, in many countries, assumed ...
Juliana Pondé Fonseca
doaj   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

open access: yesFEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada   +7 more
wiley   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

open access: yesFEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa   +4 more
wiley   +1 more source

Virtuous Violence and the Politics of Statecraft in Machiavelli, Clausewitz and Weber [PDF]

open access: yes, 2010
This article seeks to problematise the dominant understandings of the relationship between politics and violence in political theory. Liberal political theory identifies politics with the pacified arena of the modern state; although violence may ...
Frazer, Elizabeth   +3 more
core   +1 more source

Politics and society: social theory in a time of austerity - Antonio Casimiro Ferreira Porto

open access: yesBrazilian Journal of Empirical Legal Studies, 2015
A review of Antonio Casimiro Ferreira Porto's book, "Politics and society: social theory in a time of austerity", by Wanda Capeller.
Wanda Capeller
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou   +16 more
wiley   +1 more source

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