Results 191 to 200 of about 281,146 (362)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Quantized field with excitations of spacetime. [PDF]

Sci Rep
Yau H.
europepmc   +1 more source

Twenty years of the theory of relativity [PDF]

, 1927
A Libický
openalex   +1 more source

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

FEBS Open Bio, EarlyView.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley   +1 more source

The Theory of Relativity: Three Lectures for Chemists [PDF]

, 1924
Erwin Freundlich
openalex   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Thirring: DIE GESCHICHTE DER ATOMBOMBE/de Broglie: L'OPTIQUE ELECTRONIQUE/Slater: MICROWAVE TRANSMISSION/Lindsay: AN INTRODUCTION TO PHYSICAL STATISTICS/Bergmann: INTRODUCTION TO THE THEORY OF RELATIVITY/Reichenbach: PHYLOSOPHIC FOUNDATIONS OF QUANTUM MECHANICS/Bridgman: THE NATURE OF THERMODYNAMICS/Dunning und Paxton: MATTER, ENERGY, AND RADIATION/Fermi: NUCLEAR PHYSICS/Lemon und Ferrence: ANALYTICAL EXPERIMENTAL PHYSICS/Gamow: THE BIRTH AND DEATH OF THE SUN/„DER ANFANG ODER DAS ENDE?”︁ [PDF]

, 1947
Geschichte Die, Atombombe Der, Thining Hans   +2 more
openalex   +1 more source

The low-fat, low-carb debate and the theory of relativity.

American Journal of Clinical Nutrition, 2015
C. Apovian
semanticscholar   +1 more source

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

FEBS Open Bio, EarlyView.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui   +3 more
wiley   +1 more source

(Finite-Time) Thermodynamics, Hyperbolicity, Lorentz Invariance: Study of an Example. [PDF]

Entropy (Basel)
Guy B.
europepmc   +1 more source