Results 61 to 70 of about 242,723 (257)

Lacunae in the philosophical foundations of special relativity

Open Astronomy
Based on the two postulates of the invariance of both the laws of physics and light speed in inertial frames, Einstein revolutionised the prevalent conceptions of space and time in the Special Theory of Relativity, which is not however without ...
Debono Franco
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Physical Justifications and Possible Astrophysical Manifestations of the Projective Theory of Relativity

Universe, 2019
The ‘projective theory of relativity’ is a theory developed historically by Oswald Veblen and Banesh Hoffmann, Jan Arnoldus Schouten and David van Dantzig.
Jacques L. Rubin
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Teaching general relativity theory in high school: why, what and how

Revista de Enseñanza de la Física, 2017
In this work, which is part of a wider research, the problem of teaching the General Theory of Relativity in sec-ondary school is addressed, even though this theory is scarcely addressed even in physics degree courses.
Irene Arriassecq, Esther Cayul, Ileana M. Greca   +2 more
doaj  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Design, analysis and reformulation of a didactic sequence for teaching the special theory of relativity in high school

Revista Brasileira de Ensino de Física
In this work, we design, implement and analyze a didactic sequence for the teaching of the basic topics of special relativity theory in high school. The sequence proposes a series of situations, specially designed to allow the emergence of the central ...
María Rita Otero, Marcelo Arlego, Fabiana Prodanoff   +2 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Oral surveillance and JAK inhibitor safety: the theory of relativity. [PDF]

Nat Rev Rheumatol, 2022
Winthrop KL, Cohen SB.
europepmc   +1 more source

First-Order Logic Investigation of Relativity Theory with an Emphasis on Accelerated Observers [PDF]

, 2010
Gergely Székely
openalex   +2 more sources