Results 61 to 70 of about 283,444 (362)

The effective field theory treatment of quantum gravity

open access: yes, 2012
This is a pedagogical introduction to the treatment of quantum general relativity as an effective field theory. It starts with an overview of the methods of effective field theory and includes an explicit example.
Donoghue, John F.
core   +1 more source

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

open access: yesFEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman   +3 more
wiley   +1 more source

Numerical Relativity as a New Tool for Fundamental Cosmology

open access: yesPhysics, 2022
Advances in our understanding of the origin, evolution, and structure of the universe have long been driven by cosmological perturbation theory, model building, and effective field theory.
Anna Ijjas
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Derivation method of numerous dynamics in the Special Theory of Relativity

open access: yesOpen Physics, 2019
The article presents innovative method of deriving dynamics in the Special Theory of Relativity. This method enables to derive infinitely many dynamics in relativistic mechanics. The authors have shown five examples of these derivations.
Szostek Roman
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

open access: yesFEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

A física clássica de cabeça para baixo: como Einstein descobriu a teoria da relatividade especial

open access: yesRevista Brasileira de Ensino de Física
Albert Einstein por duas vezes alterou de maneira profunda nossos conceitos de espaço e tempo com a sua teoria da relatividade: primeiro no âmbito da teoria especial de 1905 e depois com a teoria geral de 1915.
Jürgen Renn
doaj   +1 more source

Lectures on faster-than-light travel and time travel

open access: yesSciPost Physics Lecture Notes, 2019
These lecture notes were prepared for a 25-hour course for advanced undergraduate students participating in Perimeter Institute's Undergraduate Summer Program.
Barak Shoshany
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

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