Results 121 to 130 of about 168,624,924 (258)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Simulation-Based Prediction of the Cold Start Behavior of Gerotor Pumps for Precise Design of Electric Oil Pumps

Applied Sciences
The development of electric gerotor pumps is a complex multiphysical optimization problem. To develop optimal systems, accurate simulation models are required to increase digital reliability.
Sven Schumacher, Ralf Stetter, Markus Till, Nicolas Laviolette, Benoît Algret, Stephan Rudolph   +5 more
doaj   +1 more source

[VisConnectome: an independent and graph-theory based software for visualizing the human brain connectome]. [PDF]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2019
Wang Y, Zhu L, He Z, Yang W, Tian G, Shen J, Luo Y.   +6 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

From user requirements to software specifications: An approach based on problem transformation

, 2013
This paper aims at deriving software specification descriptions from elicited user requirements and domain descriptions. It provides an approach to transforming user requirements into software specifications in a smooth and logical way. Based on previous
Li, Zhi, Jin, Zhi
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Industrial Perception of Legacy Software System and their Modernization [PDF]

, 2014
Research in legacy system modernization has traditionally focused on its technical challenges, and takes the standpoint that legacy systems are obsolete systems, yet they are crucial for an organization's operation.
Batlajery, Belfrit, Khadka, Ravi, Jansen, Slinger, Software Production, Saeidi, Amir, Hage, J., Software Technology, Saeidi, Amir M., Hage, Jurriaan; id_orcid, Batlajery, Belfrit V., Sub Software Technology, Sub Software Production   +11 more
core  

Quantum Vision Transformers for Quark–Gluon Classification

Axioms
We introduce a hybrid quantum-classical vision transformer architecture, notable for its integration of variational quantum circuits within both the attention mechanism and the multi-layer perceptrons.
Marçal Comajoan Cara, Gopal Ramesh Dahale, Zhongtian Dong, Roy T. Forestano, Sergei Gleyzer, Daniel Justice, Kyoungchul Kong, Tom Magorsch, Konstantin T. Matchev, Katia Matcheva, Eyup B. Unlu   +10 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

A software system for density game analysis of supply side symbiosis behaviour of green buildings considering the construction market carrying capacity

, 2017
A software system for density game analysis of supply side symbiosis behaviour of green buildings considering the construction market carrying ...
Huang, D., Li, Shuliang
core