Results 81 to 90 of about 1,380,453 (343)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Corporate governance, firm characteristics, external environment and performance of financial institutions in Uganda: A review of literature

Cogent Business & Management, 2016
Main Objective of the Study: Examine the relationship among corporate governance, firm characteristics, external environment, and performance of financial institutions in Uganda.
Juliet Wakaisuka-Isingoma, Josiah Aduda, Gituro Wainaina, Cyrus Iraya Mwangi   +3 more
doaj   +1 more source

Capabilities and the Theory of the Firm [PDF]

The recent decade has witnessed a strong expansion of work on the firm, both from a capabilities perspective and from a contractual perspective. These two bodies of theories are often thought to be fundamentally different, because their domains of ...
Nicolai J. Foss
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Pengaruh Pengungkapan Corporate Social Responsibility Pada Nilai Perusahaan Dengan Manajemen Laba Sebagai Variabel Moderasi

Jurnal Ilmiah Akuntansi dan Bisnis, 2019
The study aims to determine the effect of Corporate Social Responsibility disclosure on firm value and to determine earnings management moderate the effect of Corporate Social Responsibility disclosure on firm value.
Kalvarina Sabatini, I Putu Sudana
doaj   +1 more source

The theory of the firm [PDF]

, 1987
January 1987, first draft, May 1987, latest ...
Holmstrm, Bengt, Tirole, Jean
core  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Absorptive capacity in a more (or less) absorptive environment: A meta‐analysis of contextual effects on firm innovation

The Journal of product innovation management
The effects of the knowledge environment on a firm's ability to acquire, assimilate, transform, and utilize new knowledge—its absorptive capacity (AC)—to produce innovation (INN) have been largely overlooked in prior literature.
Tatiana R. Stettler, Esther J. Moosauer, Simone A. Schweiger, Artur Baldauf, D. Audretsch   +4 more
semanticscholar   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Contributions of Huerta de Soto to the Understanding of the Firm

Mises
This article analyzes Prof. Huerta de Soto’s contributions to entrepreneurship, focusing on their relevance for understanding the firm and its internal organization. While his conception of Perceptiveness and his Theory of Dynamic Efficiency are usually
Artur Marion Ceolin
doaj   +1 more source