Results 211 to 220 of about 6,560,912 (366)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Supplementary Material for: Distinct Gene Expression Patterns Defining Human Osteoblasts' Response to BMP2 Treatment: Is the Therapeutic Success All a Matter of Timing?

, 2016
Sabrina Ehnert, Romina H. Aspera-Werz, Thomas Freude, Marie K. Reumann, Björn Gunnar Ochs, Christian Bahrs, Steffen Schröter, Elke Wintermeyer, Andreas K. Nüssler, Stefan Pscherer   +9 more
openalex   +1 more source

Decreases in Dietary Glycemic Index Are Related to Weight Loss among Individuals following Therapeutic Diets for Type 2 Diabetes [PDF]

, 2011
Gabrielle Turner‐McGrievy, David J.A. Jenkins, Neal D. Barnard, Joshua Cohen, Lise Gloede, Amber A. Green   +5 more
openalex   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Repurposing Tumor Cells: A Paradigm Shift in Cell-Based Therapies for Cancer. [PDF]

Clin Cancer Res
Chen KS, Lin LY, Chen YC, Shah K.
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Therapeutic Interaction: A Perception of Therapist towards Patients with Anxiety Disorder

, 2015
Iosr Journals, Uzma Zaidi
openalex   +1 more source

THERAPEUTIC EFFICACY OF CHITOSAN NANOPARTICLES AND ALBENDAZOLE IN INTESTINAL MURINE TRICHINELLOSIS [PDF]

, 2018
Nashaat E. Nassef, Ismail M. Moharm, Amany F. Atia, REHAM BRAKAT, Noha Abou Hussien, Asmaa Mohamed   +5 more
openalex   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Comments regarding "Effects of therapeutic interventions on long COVID: a meta-analysis of randomized controlled trials". [PDF]

EClinicalMedicine
Tuller D.
europepmc   +1 more source