Results 201 to 210 of about 196,468 (295)

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao   +5 more
wiley   +1 more source

A Microfluidic Gradient Generator Post‐Modified by Two‐Photon Direct Laser Writing for Dynamic Particle Functionalization

open access: yesJournal of Applied Polymer Science, EarlyView.
We present a Christmas‐tree‐shaped microfluidic gradient generator (MGG) that is equipped with dynamic trapping chambers, based on thermoresponsive microactuators. At room temperature, amine‐functionalized polystyrene beads are trapped inside the pNIPAM funnels and fluorescently labeled.
Chantal Barwig   +6 more
wiley   +1 more source

The internal crest anatomy of Lambeosaurini (Hadrosauridae: Lambeosaurinae)

open access: yesThe Anatomical Record, EarlyView.
Abstract The supracranial crests of lambeosaurine hadrosaurids have long been a focus of study due primarily to their extreme morphology. The external anatomy of lambeosaurine crests is understood to be highly variable between species, but variation in their internal anatomy is less well understood.
Thomas W. Dudgeon   +2 more
wiley   +1 more source

Distinct Effects of Complement C4A and C4B Copy Numbers in Systemic Sclerosis Serological and Clinical Subtypes

open access: yesArthritis &Rheumatology, EarlyView.
Objective Complement component 4 (C4), encoded by C4A and C4B within the major histocompatibility complex (MHC) on chromosome 6, regulates the immune response and clears immune complexes. The variable copy number (CN) of C4 genes and retroviral human endogenous retrovirus K (HERV‐K) element influence its function.
Javier Martínez‐López   +156 more
wiley   +1 more source

Does the Digital Therapeutic Alliance Exist? Integrative Review.

open access: yesJMIR Ment Health
Malouin-Lachance A   +3 more
europepmc   +1 more source

Impact of evolving treatment patterns on interstitial lung disease progression in systemic sclerosis using the EUSTAR database

open access: yesArthritis &Rheumatology, Accepted Article.
Background The treatment landscape for systemic sclerosis‐associated interstitial lung disease (SSc‐ILD) has evolved with increasing immunosuppressive (IST) and anti‐fibrotic therapies available. However, their real‐world use remains unclear. Objectives To analyze treatment trends and the effect of IST and anti‐fibrotic therapies on ILD progression ...
Corrado Campochiaro   +17 more
wiley   +1 more source

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