Results 241 to 250 of about 2,620,997 (289)

Modulating the Gut Microbiome as a Therapeutic Approach in Multiple Sclerosis: Implications for Gut-Brain Interactions and Immune Pathways: A Narrative Review. [PDF]

Brain Behav
Thalib HI, Fatima N, Fakruddin FH, Ali HH, Khan S, Zubair MTM, Pereira M, Sayed Hassan FE.   +7 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Targeting Gut Microbiome Dysbiosis as a Potentially Effective Therapeutic Approach for the Treatment of Heart Failure. [PDF]

Rev Cardiovasc Med
Karmazyn M.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Sphingosine-1-Phosphate Regulation to Alleviate Sickle Cell Disease Severity: A Promising Therapeutic Approach. [PDF]

Saudi Med J
Chathoth S.
europepmc   +1 more source

Correction: Plant-derived extracellular vesicles: an alternative and complementary therapeutic approach for genitourinary tumors. [PDF]

Front Cell Dev Biol
Huang Y, Zhang Y, Lou K, Feng S, Feng G.
europepmc   +1 more source

SLC38A9 Regulation Affects Hippocampal Neuronal Autophagy: A Potential Alzheimer's Therapeutic Approach by Suppressing Alzheimer's Disease-Related Protein Deposition. [PDF]

CNS Neurosci Ther
Chen Y, Ji X, Zhao J, Bao Z, Huang Y.
europepmc   +1 more source

Opioid peptides in autism spectrum disorder and gluten-free casein-free diet as a therapeutic approach. [PDF]

Metab Brain Dis
Öztürk E, Aslan Çi̇n NN, Cansu A, Akyol A.   +3 more
europepmc   +1 more source

Tapinarof Nanogels as a Promising Therapeutic Approach. [PDF]

Pharmaceutics
Balogh B, Pető Á, Fehér P, Ujhelyi Z, Bácskay I.   +4 more
europepmc   +1 more source