Results 151 to 160 of about 6,648,309 (299)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Collective Equipoise, Disappointment and the Therapeutic Misconception: On the Consequences of Selection for Clinical Research [PDF]

Private information induces individuals to self-select as subjects into clinical research trials, and it induces researchers to select which trials they conduct.
Margaret M. Byrne, Peter Thompson
core  

Mechanisms and Novel Therapeutic Approaches for Gliomas. [PDF]

Biomedicines
Chatziathanasiadou MV.
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Results from clinical studies on new therapeutic approaches

, 2008
This is a review concerning new therapeutic approaches of acne: available treatments, combined therapy, and maintenance therapy are revised on the basis of both scientific literature and our clinical ...
MINGHETTI, Sara, VIRGILI, Anna, BORGHI, Alessandro, Bettoli V., Mantovani L.   +4 more
core  

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Exploring the therapeutic approaches for the treatment of atopic eczema by western medical herbalists: a qualitative study

, 2013
Introduction - Atopic eczema (AE) is a common inflammatory skin disorder, affecting one in five children and one in twelve adults in the UK. Due to the chronic nature of the condition and its poor management by conventional therapies, AE sufferers ...
Maraki, Z., Green, J.
core  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Special Issue "Leishmaniasis: Pathophysiology, Diagnostics and Current and Emerging Therapeutic Approaches". [PDF]

Biomedicines
Sampaio RNR, Amato VS, Souza RM, Barroso DH, Viana JVM.   +4 more
europepmc   +1 more source