Results 31 to 40 of about 2,287,905 (282)

Engineering design of platelet-mimicking therapeutic systems: multilevel biomimicry, gating strategies, and translational boundaries

Frontiers in Bioengineering and Biotechnology
Platelet-mimicking therapeutic systems have expanded well beyond hemostasis, yet clinical translation is increasingly constrained by controllability and safety-bounded deployability rather than proof-of-function. Here, we propose an engineering framework
Jiali Chen, Xiangyu Chen, Liang Cai
doaj   +1 more source

Journey of therapeutic antibodies: from discovery to future [PDF]

Exploration of Drug Science
Antibodies currently represent a leading segment of the biopharmaceutical market and are expected to maintain a significant presence in the therapeutic landscape. Development of therapeutic antibodies represents one of the most transformative advances in
Abhay H. Pande, Sandeep, J. Anakha
doaj   +1 more source

Teaching Forensic Social Work: Innovative Education through Service-Learning

Journal of Forensic Social Work, 2023
The high impact, experiential education of service-learning was utilized in a Forensic Social Work class to enhance students’ social work skills.  Students and faculty, along with another community partner provided animal-assisted grief support groups ...
Yvonne Eaton-Stull, Noelle Potts, Serena Pridgen, Doris Farren   +3 more
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Enabling Environments? A Spotlight on Community Mental Health Team Offices in Wales

BJPsych Open
Aims: A CMHT office should provide a comfortable, supportive, and therapeutic environment for staff and visitors. It should be accessible and welcoming, it should support the development and maintenance of good relationships, recognition of boundaries ...
Oliver John, Shane Mills, Adrian Clarke, Alka Ahuja, Dafydd Huw   +4 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

A perspective on meta-boundaries

, 2022
The judicious design of electromagnetic boundary provides a crucial route to control light-matter interactions, and it is thus fundamental to basic science and practical applications.
Xinyan Zhang (655654), Ruoxi Chen (110319), Jialin Chen (451414), Hongsheng Chen (828171), Xiao Lin (20892), Tong Cai (2108584), Chan Wang (296736)   +6 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source