Results 151 to 160 of about 1,472,669 (399)

Open‐source maximum a posteriori‐bayesian dosing AdDS to current therapeutic drug monitoring: Adapting to the era of individualized therapy [PDF]

, 2021
Nicholas M. Smith, Arthur W.K. Chan, Laura A. Wilkinson, Hubert C. Chua, Thomas D. Nguyen, Harriet de Souza, Anant P. Shah, David Z. D’Argenio, Kari A. Mergenhagen   +8 more
openalex   +1 more source

Monographs on drugs which are frequently analyzed in therapeutic drug monitoring/Arzneimittel-Monographien für Medikamente, die regelmäßig im Rahmen des Therapeutic Drug Monitorings analysiert werden [PDF]

, 2017
In addition to the monographs which have been published in the last 6 years by the working group "Drug Monitoring” of the Swiss Society of Clinical Chemistry (SSCC) [Rentsch, Fathi, Grignaschi, Magnin, Printzen, Thormann, J Lab Med 29: 287-97, 2005 ...
Buhl, Daniela, Eap, Chin Bin, Fathi, Marc, Rentsch, Katharina, Thormann, Wolfgang, Werner, Dominique   +5 more
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Knowledge, Attitude and Practices (K.A.P.) of doctors prescribing Vancomycin in a tertiary care hospital towards Therapeutic Drug Monitoring (T.D.M.) of Vancomycin

Recent Trends in Pharmacology
Objective: Vancomycin is frequently prescribed to treat infections caused by methicillin-resistant Staphylococcus aureus. Precise dosing through therapeutic drug monitoring is critical for optimising treatment outcomes, minimising toxicity, and reducing ...
Sujeet Bhilwade, Bhaskar Krishnamurthy, Vinayak A, Mahesh Belhekar   +3 more
doaj   +1 more source

Naltrexone therapeutic drug monitoring: A case series

Psychiatry and Clinical Psychopharmacology, 2021
Objective: Naltrexone is an opioid receptor antagonist.It is used in maintanence treatment of opiate dependence,alcohol dependence, prevention of relapse of alcohol dependence, treatment of cocaine dependence, nicotine dependence, eating disorders ...
Birim Sungu Danışmant, Nesrin Dilbaz, Esra Sağlam, Kaşif Nevzat Tarhan   +3 more
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Therapeutic Drug Monitoring of the Newer Anti-Epilepsy Medications

Pharmaceuticals, 2010
In the past twenty years, 14 new antiepileptic drugs have been approved for use in the United States and/or Europe. These drugs are eslicarbazepine acetate, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, pregabalin ...
Matthew D. Krasowski
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Phenytoin: A Guide to Therapeutic Drug Monitoring

Proceedings of Singapore Healthcare, 2013
Therapeutic drug monitoring of phenytoin is carried out to ensure effective and safe levels. Some of the factors complicating phenytoin dosing include a narrow therapeutic window, high degree of protein binding, and nonlinear pharmacokinetics.
Melissa Faye Wu BSc (Pharm) (Hons), Wai Hing Lim B.Pharm (Hons), M Clin Pharm   +1 more
doaj   +1 more source

[Translated article] Therapeutic drug monitoring of voriconazole in a rapid-metabolizer patient with invasive pulmonary aspergillosis

, 2023
Jorge Esquivel Negrín, E Tévar Alfonso, Ruth López Travieso, Jesús Rodríguez González, J Merino Alonso, Andrea Santos Fagundo   +5 more
openalex   +1 more source