Results 161 to 170 of about 1,472,669 (399)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Impact of high plasma concentrations of linezolid in Taiwanese adult patients— therapeutic drug monitoring in improving adverse drug reactions

, 2020
Chih‐Ning Cheng, Chien‐Chih Wu, Ching‐Hua Kuo, Chi‐Chuan Wang, Jann‐Tay Wang, Ya‐Ting Lin, Ren-Shiang Jhang, Shu‐Wen Lin   +7 more
openalex   +1 more source

P654 Advances in optimalisation of therapeutic drug monitoring using mucosal TNF expression and anti-TNF concentration in patients with inflammatory bowel disease treated with biologicals: Preliminary results from a single-centre study [PDF]

, 2018
Klaudia Farkas, Gréta Elekes, D Kata, Imre Földesi, Steven M. Lada, Tamás Ferenci, Tamara Madácsy, Mariann Rutka, Anita Bálint, Renáta Bor, Anna Fábián, Ágnes Milassin, Zoltán Szepes, Ferenc Nagy, József Maléth, Tamás Molnár   +15 more
openalex   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Diverse Drug Classes Partition into Human Sweat: Implications for Both Sweat Fundamentals and for Therapeutic Drug Monitoring

, 2023
Theresa Ruwe, Evyn White, Aidan S. Zebertavage, David Runnoe, Dan Fay, Henry Daumeyer, Timothy S. Tracy, Kara Fay Uchtman, Gavi Begtrup, Yuchan Yuan, Jason Heikenfeld, William A. Buggele   +11 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Therapeutic drug monitoring of biologics in psoriasis

Biologics: Targets & Therapy, 2019
MeiQi May Liau,1 Hazel H Oon2 1Division of Dermatology, University Medicine Cluster, National University Hospital, Singapore; 2National Skin Centre, Singapore Abstract: Biologics are an important component of the armamentarium of drugs in the treatment ...
Liau MM, Oon HH
doaj  

The Role of Therapeutic Drug Monitoring in Children [PDF]

, 2023
Alexander Nasr, Phillip Minar
openalex   +1 more source

What Makes A Court Problem-Solving: Universal Performance Indicators for Problem-Solving Justice [PDF]

, 2010
This report identifies a set of universal performance indicators for specialized "problem-solving courts" and related experiments in problem-solving justice.
Adam Mansky, Michael Rempel, Rachel Porter   +2 more
core