Results 321 to 330 of about 678,102 (350)
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Acta Neuropsychiatrica, 1999
SUMMARYThe cytochrome P450 iso-enzyme system plays a key role in the biotransformation of many drugs, including psychotropics. Its activity is determined by both genetic and environmental factors. The most important iso-enzymes for psychiatry in general are P450 IID6, 3A4 and 1A2.
J B, Noten +3 more
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SUMMARYThe cytochrome P450 iso-enzyme system plays a key role in the biotransformation of many drugs, including psychotropics. Its activity is determined by both genetic and environmental factors. The most important iso-enzymes for psychiatry in general are P450 IID6, 3A4 and 1A2.
J B, Noten +3 more
openaire +2 more sources
Therapeutic Drug Monitoring of Voriconazole
Therapeutic Drug Monitoring, 2008Voriconazole is a triazole antifungal developed for the treatment of life-threatening fungal infections in immunocompromised patients. The drug, which is available for both oral and intravenous administration, has broad-spectrum activity against pathogenic yeasts, dimorphic fungi, and opportunistic molds.
Bruggemann, R.J.M. +7 more
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TDM: Therapeutic Drug Measuring or Therapeutic Drug Monitoring?
Therapeutic Drug Monitoring, 2005The third round of the International Interlaboratory Quality Control Program for Therapeutic Drug Monitoring in HIV infection (QC-program) consisted of the analysis not only of plasma samples but also of patient cases. The case was composed of different topics related to the therapeutic drug monitoring of antiretroviral drugs.
Droste, J.A.H. +3 more
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2014
Only a small fraction of drugs (approximately 50) out of over 3,000 prescription drugs require therapeutic drug monitoring; usually 20–30 drugs are routinely monitored in most hospital laboratories. Immunoassays are available for monitoring 26 drugs, while for monitoring less frequently ordered drugs, chromatographic techniques must be used.
Amitava Dasgupta, Amer Wahed
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Only a small fraction of drugs (approximately 50) out of over 3,000 prescription drugs require therapeutic drug monitoring; usually 20–30 drugs are routinely monitored in most hospital laboratories. Immunoassays are available for monitoring 26 drugs, while for monitoring less frequently ordered drugs, chromatographic techniques must be used.
Amitava Dasgupta, Amer Wahed
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Therapeutic Drug Monitoring of Lamotrigine
Annals of Pharmacotherapy, 2002OBJECTIVE: To evaluate the usefulness of routine monitoring of serum lamotrigine concentration. DATA SOURCE: Literature was accessed through MEDLINE (1990–January 2001). Key search terms included lamotrigine, pharmacokinetics, and epilepsy. DATA SYNTHESIS: A decision-making algorithm was used to evaluate the clinical evidence to support or refute the ...
Elaine Chong, L. Lee Dupuis
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Therapeutic drug monitoring for triazoles
Current Opinion in Infectious Diseases, 2008Invasive fungal infections are a leading cause of morbidity and mortality in immunocompromised patients, and mechanisms to optimize therapeutic outcomes are urgently required. Therapeutic drug monitoring represents an important component for the routine use of the triazoles.Triazoles have revolutionized the prevention and treatment of invasive fungal ...
Hope, William W. +3 more
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Therapeutic drug monitoring of cyclosporine
Transplantation Proceedings, 2004Therapeutic drug monitoring of cyclosporine has been established as part of the routine clinical treatment for patients after organ transplantation. The inability to define optimal dose (maximize efficacy/minimize toxicity) has been a problem related to drug monitoring of cyclosporine.
David W. Holt, Atholl Johnston, A Jorga
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Therapeutic Drug Monitoring of Antiarrhythmic Drugs
Clinical Pharmacokinetics, 2003Most antiarrhythmic drugs fulfil the formal requirements for rational use of therapeutic drug monitoring, as they show highly variable plasma concentration profiles at a given dose and a direct concentration-effect relationship. Therapeutic ranges for antiarrhythmic drugs are, however, often very poorly defined.
Jens Peter Kampmann +2 more
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Glucuronidation in therapeutic drug monitoring
Clinica Chimica Acta, 2005Glucuronidation is a major drug-metabolizing reaction in humans. A pharmacological effect of glucuronide metabolites is frequently neglected and the value of therapeutic drug monitoring has been questioned. However, this may not always be true.In this review the impact of glucuronidation on therapeutic drug monitoring has been evaluated on the basis of
Maria Shipkova, Eberhard Wieland
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