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Exploring EMDR: an innovative approach with Posner Paradigm to reprocessing negative memories in a non-clinical sample. [PDF]
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The therapeutic equivalence of complex drugs
Regulatory Toxicology and Pharmacology, 2011When the patent of a small molecule drug expires generics may be introduced. They are considered therapeutically equivalent once pharmaceutical equivalence (i.e. identical active substances) and bioequivalence (i.e. comparable pharmacokinetics) have been established in a cross-over volunteer study.
Huub Schellekens +2 more
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On the Definition of Therapeutic Equivalence
Drug Information Journal, 2000What do we mean by therapeutic equivalence and how do we prove that two drugs are therapeutically equivalent? We suggest that therapeutic equivalence should be defined and demonstrated using predefined limits on the dose scale rather than on the effect scale.
Anders Kallen
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Therapeutic equivalence: fallacies and falsification
Statistics in Medicine, 2003AbstractThe number of studies designed specifically to demonstrate therapeutic equivalence or alternatively non‐inferiority of pharmaceutical treatments has increased dramatically in recent years, during which time awareness of the methodological issues has increased. Regulatory authorities have been quick to recognize the need for specific support and
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Methodological standards for assessing therapeutic equivalence
Journal of Clinical Epidemiology, 1991This paper reviews issues related to defining and demonstrating therapeutic equivalence. A set of guidelines are proposed to critically review clinical trials to determine whether there is sufficient evidence to conclude that an experimental therapy is therapeutically equivalent to a standard one. These guidelines include criteria for assessing whether
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Understanding Therapeutic Equivalence in Epilepsy
CNS Spectrums, 2010ABSTRACTThe issues surrounding generic drug substitution in patients with epilepsy are complex.The substitution of one formulation of an antiepileptic drug (AED) for another is controversial. Well-reasoned and defensible cases can be made both for and against such substitution.
Raman, Sankar, Tracy A, Glauser
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GENERIC DRUGS AND THERAPEUTIC EQUIVALENCE
JAMA: The Journal of the American Medical Association, 1968In recent years, there has developed the belief that nonproprietary or generic drugs are much cheaper than, and as effective as, trade-named items. This belief has led to a widespread demand that prescribing and use of generic drugs be encouraged. Studies conducted by impartial groups such as the Medical Letter on Drugs and Therapeutics have applied ...
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On Therapeutic Equivalency and the Antisubstitution Laws
JAMA: The Journal of the American Medical Association, 1973The comparative bioavailability of a drug in similarly formulated preparations is becoming a subject of considerable interest and importance to the physician. Drugs usually are not administered as pure compounds but are combined with materials such as binders, excipients, lubricants, preservatives, or other substances generally considered to be ...
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Therapeutic equivalency of two lidocaine preparations
American Journal of Health-System Pharmacy, 1976Twenty-five volunteers were studied as to the onset and duration of action of two commercial brands of lidocaine. One and two percent concentrations of the preparations were tested intradermally using a double-blind, cross-over protocol. Both needle-drop and electrical stimulation techniques were employed as the source of pain stimulus. Five additional
J E, Stambaugh +2 more
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