Results 161 to 170 of about 3,107,552 (340)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Innovative in vitro methodologies for establishing therapeutic equivalence

Revista Panamericana de Salud Pública
To improve the quality of pharmaceutical products in their markets, several Latin American countries have begun to require that new generic products demonstrate bioequivalence against innovator or reference products. However, given the number of products
Lisa Murray, Antonio Arias, Jibin Li, Sid Bhoopathy, Ismael J. Hidalgo   +4 more
doaj  

Effect of Unintentional Storage and Handling Errors of Inhaled Medications: What Does This Mean for Therapeutic Equivalence Considerations? [PDF]

J Aerosol Med Pulm Drug Deliv, 2019
Wolkenhauer M, Latza K, Jung J, Eckhard N, Götzmann F.   +4 more
europepmc   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Therapeutic Equivalence of Eyluxvi (Aflibercept) to Eylea in Neovascular Age-Related Macular Degeneration: ALTERA Trial (Randomized). [PDF]

Ophthalmol Ther
Raczynska D, Ernest J, Baumane K, Sagong M, Akiyama K, Rauschning W, Vajas A, Nowosielska A, Dusova J, Majtánová N, Oleksy P, Kuneva I, Resch M, Lange N, Briede E, Bajdik B, Jeong A, Kozub B, Papp A.   +18 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

LUMIADE 3: Therapeutic Equivalence of Denosumab Biosimilar FKS518 to Reference Product in Postmenopausal Osteoporosis. [PDF]

J Endocr Soc
Krecipro-Nizinska E, Pluskiewicz W, Supronik J, Szeles P, Petit-Frere C, Varone E, Ferrari S, Valter I.   +7 more
europepmc   +1 more source

Demonstration of Therapeutic Equivalence of Fluconazole Generic Products in the Neutropenic Mouse Model of Disseminated Candidiasis. [PDF]

PLoS One, 2015
Gonzalez JM, Rodriguez CA, Zuluaga AF, Agudelo M, Vesga O.   +4 more
europepmc   +1 more source

Therapeutic Equivalence/Generic Substituton [PDF]

Journal of Korean Society for Clinical Pharmacology and Therapeutics, 2000
openaire   +1 more source