Results 71 to 80 of about 3,107,552 (340)

Authorized Generic Entry prior to Patent Expiry: Reassessing Incentives for Independent Generic Entry [PDF]

, 2010
Patent holders frequently attempt to mitigate the loss of monopoly power by authorizing generic entry prior to patent expiry (early entry). Competition in off-patent pharmaceutical markets may be adversely affected if early entry substantially impairs ...
Appelt, Silvia
core   +4 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Mindfulness-based cognitive therapy v. group psychoeducation for people with generalised anxiety disorder: randomised controlled trial [PDF]

, 2016
Background: Research suggests that an 8-week mindfulness-based cognitive therapy (MBCT) course may be effective for generalised anxiety disorder (GAD).
Chan, Peter Hoi Sing, Cheung, Eliza Yee Lai, Gao, Ting, Griffiths, Sian M., Lee, Tatia Mei Chun, Ling, Candy Yuet Man, Lo, Herman Hay Ming, Lui, Wacy Wai Sze, Ma, Helen Shuk Wah, Mak, Winnie Wing Sze, Mercer, Stewart, Tang, Wai Kwong, Wong, Samuel Yeung Shan, Wu, Justin Che Yuen, Yip, Benjamin Hon Kei   +14 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Interchangeable medicines: impact of expenses from the perspective of customers of a startup from Minas Gerais

Jornal de Assistência Farmacêutica e Farmacoeconomia
Objectives: The objective of this study was to conduct a cost-minimization evaluation of the potential interchangeability between prescribed medications from the patient’s pers-pective, using information from Far.me, a startup that offers individualized
Cícero Quintão Celestino, Samilla Dornellas Faria, Ronaldo Portela, Isabella Piassi Dias Godói, Cristina Mariano Ruas   +4 more
doaj   +1 more source

Non-equivalence of antibiotic generic drugs and risk for intensive care patients [PDF]

, 2013
Background: The underlying axiom in applying generic drugs is the equivalence of their active ingredient with the (usually more expensive) innovator product, an all-embracing statement with the insidious result that physicians assume that the generic ...
Barbeck, Mike, Ghanaati, Shahram, Kirkpatrick, Charles James, Rangoonwala, Ramzan, Reshetnykov, Mykhaylo   +4 more
core  

Three-Dimensional (3D) Printed Microneedles for Microencapsulated Cell Extrusion [PDF]

, 2018
Cell-hydrogel based therapies offer great promise for wound healing. The specific aim of this study was to assess the viability of human hepatocellular carcinoma (HepG2) cells immobilized in atomized alginate capsules (3.5% (w/v) alginate, d = 225 µm ...
Bouzos, Evangelia, Chau, Huong, Farias, Chantell, Hemingway, Cecilia, Lyman, Roman, Mahacek, Anne, Mobed-Miremadi, Maryam   +6 more
core   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Impact on Bacterial Resistance of Therapeutically Nonequivalent Generics: The Case of Piperacillin-Tazobactam.

PLoS ONE, 2016
Previous studies have demonstrated that pharmaceutical equivalence and pharmacokinetic equivalence of generic antibiotics are necessary but not sufficient conditions to guarantee therapeutic equivalence (better called pharmacodynamic equivalence).
Carlos A Rodriguez, Maria Agudelo, Yudy A Aguilar, Andres F Zuluaga, Omar Vesga   +4 more
doaj   +1 more source

A multicentre, multi-national, double-blind, randomised, active-controlled, parallel-group clinical study to assess the safety and efficacy of PDA10 (Epoetin-alpha) vs. Eprex® in patients with anaemia of chronic renal failure

BMC Nephrology, 2021
Background Erythropoietin stimulating agent (ESA) has been standard of care in treating renal anaemia for the past 20 years. Many patients have limited access to ESA in view of long-term costs leading to suboptimal ESA dosage.
Soo Kun Lim, Bak Leong Goh, Ravindran Visvanathan, Su Hyun Kim, Jin Seok Jeon, Sung Gyun Kim, Jae Hyun Chang, Chun Soo Lim, Zaki Morad   +8 more
doaj   +1 more source