Results 111 to 120 of about 2,453,999 (317)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Custo-efetividade dos análogos de nucleosídeos/nucleotídeos para hepatite crônica B

Revista de Saúde Pública
OBJECTIVE: To conduct a cost-effectiveness analysis of drug alternatives with rescue therapy in case of relapse due to viral resistance for the treatment of patients with chronic hepatitis B (CHB). METHODS: Hypothetical cohort of patients with CHB, HBeAg-
Alessandra Maciel Almeida, Anderson Lourenço da Silva, Cristina Mariano Ruas Brandão, Mariângela Leal Cherchiglia, Eli Iola Gurgel Andrade, Gustavo Laine Araújo de Oliveira, Ricardo Andrade Carmo, Francisco de Assis Acurcio   +7 more
doaj  

Evaluation of Sociodemographic Determinants in Narcotic Users Referring to Center for Methadone Maintenance Therapy of Yazd, Iran

Journal of Community Health Research, 2012
Introduction: Addiction is a habit or behavior that is often hard to quit. It is estimated that 190 million persons are substance users around the world. Substance abuse creates tolerance after a while.
M.H. Lotfi, M.R Vafaeinasab, M. Alimi, F. Beyzi   +3 more
doaj  

Therapeutic Hypothermia after Cardiac Arrest

, 2016
The use of therapeutic hypothermia after cardiac arrest has been shown to reduce mortality and improve neurological outcomes in several randomized controlled trials.
Omairi, Ahmad
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Terapia combinada con antibióticos: un enfoque ampliamente utilizado pero poco comprendido

Infectio
Antibiotic combination therapy is widely used in clinical practice; however, its application often lacks a clear understanding of the underlying pharmacological principles.
Diego Oquendo
doaj   +1 more source

Comparative Metabolome and Transcriptome Analyses Reveal Differential Enrichment of Metabolites with Age in Panax notoginseng Roots

Plants
Panax notoginseng is a perennial plant well known for its versatile medicinal properties, including hepatoprotective, antioxidant, anti-inflammatory, anti-tumor, estrogen-like, and antidepressant characteristics.
Xinru Yan, Ao Zhang, Yiming Guan, Jinlong Jiao, Murad Ghanim, Yayu Zhang, Xiahong He, Rui Shi   +7 more
doaj   +1 more source

The association of therapeutic versus recreational marijuana use and antiretroviral adherence among adults living with HIV in Florida

, 2018
Zachary L Mannes,1 Larry E Burrell II,1 Erin G Ferguson,1 Zhi Zhou,2,3 Huiyin Lu,4,5 Charurut Somboonwit,6 Robert L Cook,2,3 Nicole Ennis1 1Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of ...
Lu H, Cook RL, Ferguson EG, Somboonwit C, Mannes ZL, Burrell II LE, Zhou Z, Ennis N   +7 more
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Gastrointestinal Adverse Effects of Anti-Obesity Medications in Non-Diabetic Adults: A Systematic Review

Medicina
Background: With rising obesity rates, pharmacological interventions are increasingly used in non-diabetic adults. While being effective in managing weight, these agents frequently cause gastrointestinal (GI) side effects, affecting adherence and long ...
Ehab Takrori, Supriya Peshin, Sakshi Singal   +2 more
doaj   +1 more source