Results 191 to 200 of about 2,453,999 (317)

Halogen-Containing Drugs in 2025: A Record Year for the Therapeutic Use and Synthesis of FDA-Approved Small Molecules. [PDF]

Biomolecules
Benedetto Tiz D, D'Alì M, Iraci N, Santi C, Sancineto L.   +4 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Antimicrobial peptides: an overview of a promising class of therapeutics

Open Life Sciences, 2007
Giuliani Andrea, Pirri Giovanna, Nicoletto Silvia   +2 more
doaj   +1 more source

Therapeutic Use of Psilocybin in Depression: a Systematic Review of Clinical Evidence. [PDF]

Acta Neuropsychiatr
Andrade FRT, Buchborn T, Thalheimer G, Meinhardt MW, Joca S, de Almeida RMM.   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Therapeutic use of rTMS [PDF]

Nature Reviews Neuroscience, 2007
openaire   +2 more sources

Francesco Torti (1658-1741) and his description on the therapeutic use of quinine: the first effective method of treating malaria based on an extract of the bark of the Peruvian cinchona tree. [PDF]

Malariaworld J
Artico M, Costi R, Gazzaniga V, Iorio S, Pastore FS, Cofone L.   +5 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

On the Therapeutic Use of Iodoform [PDF]

BMJ, 1878
openaire   +2 more sources

Therapeutic use of highly concentrated CO₂ for wound healing: bathing and non-bathing modalities in a systematic review and meta-analysis. [PDF]

PeerJ
Chen S, Tong JY, Aslam MS.
europepmc   +1 more source