Results 231 to 240 of about 18,082,299 (299)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Current literature support and opposition for therapeutic use of selenium supplementation in autoimmune thyroid conditions. [PDF]

Biochem Biophys Rep
Nannapaneni A, Wilson V, Chughtai S.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Evaluating the therapeutic use of music to address anxiety for women undergoing gynaecological and fertility treatments. [PDF]

BMC Complement Med Ther
Short AE, Andreadis N, Cheung G, Stulz V.   +3 more
europepmc   +1 more source

The role of indigenous knowledge in advancing the therapeutic use of medicinal plants: challenges and opportunities. [PDF]

Plant Signal Behav
Alum EU.
europepmc   +1 more source

Acceptability of and attitudes to the therapeutic use of cannabis and cannabidiol in people with Parkinson's disease: A French survey. [PDF]

Clin Park Relat Disord
Barré T, Cazorla G, Di Beo V, Lopez F, Radoszycki L, Maradan G, Baunez C, Carrieri P.   +7 more
europepmc   +1 more source

Expert Consensus on Vitamin B6 Therapeutic Use for Patients: Guidance on Safe Dosage, Duration and Clinical Management. [PDF]

Drug Healthc Patient Saf
Schellack N, Yotsombut K, Sabet A, Nafach J, Hiew FL, Kulkantrakorn K.   +5 more
europepmc   +1 more source

AI-enabled drug prediction and gene network analysis reveal therapeutic use of vorinostat for Rett Syndrome in preclinical models. [PDF]

Commun Med (Lond)
Novak R, Lin T, Kaushal S, Sperry M, Vigneault F, Gardner E, Loomba S, Shcherbina K, Keshari V, Dinis A, Vasan A, Chandrasekhar V, Takeda T, Nihalani R, Umur S, Turner JR, Levin M, Ingber DE.   +17 more
europepmc   +1 more source

Therapeutic use of music listening in patients undergoing invasive coronary procedures: A meta-analysis. [PDF]

World J Cardiol
Siddiqi AK, Shafiq A, Ahmed M, Anwer A, Maniya MT, Ahmed A, Chachar MA, Hasibuzzaman MA.   +7 more
europepmc   +1 more source