Results 151 to 160 of about 4,001,428 (243)
Revista Portuguesa de Pneumologia, 2007 O quilotórax é o derrame pleural mais frequente no feto e no recém-nascido. O tratamento actual do quilotórax inclui várias e diferentes medidas terapêuticas pré e pós-natais. Os autores apresentam, de forma prática e sumária, linhas de orientação para o
Gustavo Rocha +3 more
doaj
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Therapeutical approaches for dysferlinopathies treatment
, 2010 Ce travail de thèse a porté sur le développement d'approches thérapeutiques pour les dysferlinopathies, pathologies dues à un déficit en dysferline, pour lesquelle sil n'existe pas de traitement à l'heure actuelle.
Lostal, William
core
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Pancreatic encephalopathy- a rare complication of severe acute biliary pancreatitis
Journal of Mind and Medical Sciences, 2014 Background. Pancreatic encephalopathy is a rare complication of severe acute pancreatitis, with high mortality, being difficult to diagnose and treat, thus requiring continuous research regarding its management. Materials and Methods.
Vlad Denis Constantin +3 more
doaj
Therapeutical and experimental usefulness of apomorphine
, 1981 Apomorphine induces behavioural changes in man in some way similar to those elicited by low doses of the drug in animals. In fact, in man a complex symptomatology, in which sedation and psycho-motor reduction predominates, is elicited by non-emetic doses
GESSA GL +4 more
core
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Latest Therapeutical Approaches for Triple-Negative Breast Cancer: From Preclinical to Clinical Research. [PDF]
Int J Mol SciPont M, Marqués M, Sorolla A.
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source