Results 91 to 100 of about 429,144 (355)

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Neonatal abstinence syndrome: Pharmacologic strategies for the mother and infant. [PDF]

, 2016
Opioid use in pregnancy has increased dramatically over the past decade. Since prenatal opioid use is associated with numerous obstetrical and neonatal complications, this now has become a major public health problem.
Davis, Jonathan M., Kraft, Walter K., Stover, Megan W.   +2 more
core   +2 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Gastroesophageal reflux disease and tooth erosion [PDF]

, 2011
The increasing prevalence of gastroesophageal reflux disease (GERD) in children and adults, and of “silent refluxers” in particular, increases the responsibility of dentists to be alert to this potentially severe condition when observing unexplained ...
Kaidonis, J., Ranjitkar, S., Smales, R.
core   +4 more sources

Synaptopodin is required for long-term depression at Schaffer collateral-CA1 synapses

Molecular Brain
Synaptopodin (SP), an actin-associated protein found in telencephalic neurons, affects activity-dependant synaptic plasticity and dynamic changes of dendritic spines.
Yanis Inglebert, Pei You Wu, Julia Tourbina-Kolomiets, Cong Loc Dang, R. Anne McKinney   +4 more
doaj   +1 more source

The pharmacology and therapeutic potential of (-)-huperzine A

Journal of Experimental Pharmacology, 2012
(-)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss. Due to its potent neuroprotective activities, it has been investigated as a candidate for the treatment of neurodegenerative diseases, including Alzheimer's disease. In this review, we will discuss the pharmacology and therapeutic potential of (-)-huperzine A (1).
Maung Kyaw Moe Tun, Seth B. Herzon
openaire   +5 more sources

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Hepatitis B Vaccine Nonresponse and Associated Risk Factors: Insights From a Cohort Study

Journal of Tropical Medicine
Hepatitis B virus (HBV) infection remains a critical global health issue, particularly in high-burden regions with substantial global morbidity and mortality.
Shuaibu Abdullahi Hudu, Abdulgafar Olayiwola Jimoh, Sa’adatu Haruna Shinkafi, Albashir Tahir, Ahmed Subeh Alshrari, Muhammad Tukur Umar, Abdulmajeed Yunusa, Nura Bello, Nura Abubakar   +8 more
doaj   +1 more source

Understanding Preclerkship Medical Students’ Poor Performance in Prescription Writing

Sultan Qaboos University Medical Journal, 2016
Objectives: This study aimed to explore reasons for poor performance in prescription writing stations of the objective structured practical examination (OSPE) and absenteeism in prescription writing sessions among preclerkship medical students at the ...
Henry James, Khalid A. J. Al Khaja, Yasin I. Tayem, Sindhan Veeramuthu, Reginald P. Sequeira   +4 more
doaj   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source