Results 111 to 120 of about 1,302,607 (412)
Hierarchical microplates as drug depots with controlled geometry, rigidity and therapeutic efficacy [PDF]
arXiv, 2019 A variety of microparticles have been proposed for the sustained and localized delivery of drugs whit the objective of increasing therapeutic indexes by circumventing filtering organs and biological barriers. Yet, the geometrical, mechanical and therapeutic properties of such microparticles cannot be simultaneously and independently tailored during the
arxiv
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
The Growing Class of Novel RNAi Therapeutics
Molecular PharmacologyThe clinical use of RNA interference (RNAi) molecular mechanisms has introduced a novel, growing class of RNA therapeutics capable of treating diseases by controlling target gene expression at the posttranscriptional level.
G. Traber, Aiming Yu
semanticscholar +1 more source
ATP as a presynaptic modulator [PDF]
, 2000 © 2000 Elsevier Science Inc.There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy,
Cunha, Rodrigo A., Ribeiro, J. A.
core +1 more source
A Skew Normal Model of the Dose-Effect Relation in Pharmacology [PDF]
arXiv, 2015 This paper deals with a skew-normal model of the relation between a dose $d > 0$ and a quantitative measure $E(d)$ of an effect of the administered drug. Precisely, $E(d)$ is a measure of the therapeutic response or a measure of a side-effect. Some existing and additional properties of the logistic functions are proved, and a skew-normal model of the ...
arxiv
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Emerging principles of cytokine pharmacology and therapeutics
Nature reviews. Drug discovery, 2022 R. A. Saxton, C. Glassman, K. Garcia
semanticscholar +1 more source
Pharmacy & Therapeutics Update: Drug Information for Health Care Professionals, October 2008 [PDF]
, 2008 pharmacy, pharmacology, therapeutics, medicine, drug utilization, public health, patient harm, patient safety, anticoagulants, immunization schedule, immunizationhttps://medica-musc.researchcommons.org/musc-ptupdate/1008/thumbnail ...
Bush, Paul +5 more
core +2 more sources
Breast Cancer ResearchBackground Endocrine therapy is the most important treatment modality of breast cancer patients whose tumors express the estrogen receptor α (ERα). The androgen receptor (AR) is also expressed in the vast majority (80–90%) of ERα-positive tumors.
Huanyao Gao +10 more
doaj +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source