Results 131 to 140 of about 1,302,607 (412)
FEBS Open Bio, EarlyView.Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu +4 more
wiley +1 more source
Nature Communications, 2019 The ATR pathway is active during DNA replication stress to maintain genome stability. Here the authors reveal the role of the zinc finger containing protein 161 (ZFP161) to facilitate replication fork stability by acting as a scaffold to facilitate the ...
Wootae Kim +12 more
doaj +1 more source
The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise
FEBS Open Bio, EarlyView.Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji +3 more
wiley +1 more source
Differential pharmacokinetics and pharmacokinetic/pharmacodynamic modelling of robenacoxib and ketoprofen in a feline model of inflammation [PDF]
, 2014 Robenacoxib and ketoprofen are acidic nonsteroidal anti‐inflammatory drugs (NSAIDs). Both are licensed for once daily administration in the cat, despite having short blood half‐lives.
Arifah +48 more
core +1 more source
NMR based Pharmaco-metabolomics: An efficient and agile tool for therapeutic evaluation of Traditional Herbal Medicines [PDF]
arXiv, 2016 Traditional Indian (Ayurvedic) and Chinese herbal medicines have been used in the treatment of a variety of diseases for thousands of years because of their natural origin and lesser side effects. However, the safety and efficacy data (including dose and quality parameters) on most of these traditional medicines are far from sufficient to meet the ...
arxiv
Aging and Cancer, EarlyView.Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley +1 more source
Gastroesophageal reflux disease and tooth erosion [PDF]
, 2011 The increasing prevalence of gastroesophageal reflux disease (GERD) in children and adults, and of “silent refluxers” in particular, increases the responsibility of dentists to be alert to this potentially severe condition when observing unexplained ...
Kaidonis, J., Ranjitkar, S., Smales, R.
core +4 more sources
Pharmacy & Therapeutics Update: Drug Information for Health Care Professionals, July/August 2008 [PDF]
, 2008 pharmacy, pharmacology, therapeutics, medicine, drug utilization, public health, medication errors, costs and cost analysis, drug-related side effects and adverse reactionshttps://medica-musc.researchcommons.org/musc-ptupdate/1006/thumbnail ...
Bush, Paul +4 more
core +21 more sources
Health Care Evolves From Reactive to Proactive. [PDF]
, 2019 Decoding health and disease pathways drives healthcare evolution. Historically, therapeutic paradigms have relied on interventions that mitigate symptoms of established diseases.
Terzic, Andre, Waldman, Scott A.
core +2 more sources
Journal for ImmunoTherapy of Cancer, 2019 Background The colorectal cancer antigen GUCY2C exhibits unique split tolerance, evoking antigen-specific CD8+, but not CD4+, T-cell responses that deliver anti-tumor immunity without autoimmunity in mice.
Adam E. Snook +9 more
doaj +1 more source