Results 141 to 150 of about 298,488 (253)
Retraction: AFAP1-AS1 promotes epithelial-mesenchymal transition and tumorigenesis through Wnt/β-catenin signaling pathway in triple-negative breast cancer. [PDF]
Front PharmacolFrontiers Editorial Office.
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.We developed a micro‐sized, biocompatible implant for postoperative sustained delivery of anti‐fibrotic antibodies in glaucoma surgery. Machine learning‐guided optimization of polymer composition, implant geometry, and porosity enabled precise control of drug release.
Mengqi Qin +5 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu +10 more
wiley +1 more source
The Impact of QSP Modeling on the Design and Optimization of Gene Therapy Approaches. [PDF]
CPT Pharmacometrics Syst PharmacolRayad N, Chowdhury EA, Meno-Tetang GML.
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji +7 more
wiley +1 more source
Advances in Bioprinting to Model Immune‐Mediated Skin Diseases
Advanced Healthcare Materials, EarlyView.This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández +4 more
wiley +1 more source
FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products: Selecting Optimized Dosages for Registrational Trials. [PDF]
Clin Cancer ResShord SS +8 more
europepmc +1 more source
Boron‐Doped Nano‐Crystalline Coated Carbon Fibers for Phasic Dopamine Sensing
Advanced Healthcare Materials, EarlyView.This uniform coating presents a mix of graphitic and diamond‐like carbon to create a mechanically and electrically robust alternative for the electrochemical detection of dopamine. The electrodes in this work possess the equivalent sensitivity to the state‐of‐the‐art FSCV dopamine detecting electrodes, whilst demonstrating an ability to withstand ...
Simon J. Higham +19 more
wiley +1 more source
Editorial: Non-coding RNAs as potential therapeutics and biomarkers for human diseases. [PDF]
Front PharmacolGama-Carvalho M +2 more
europepmc +1 more source