Results 261 to 270 of about 429,144 (355)

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

Advanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac, Luv Patel, Nguyen Tran, Amarnath Singam, DongSoo Yun, Prasun Guha, Seungman Park, Chandrabali Bhattacharya   +7 more
wiley   +1 more source

Novel therapeutics and pharmacology, biological approaches

, 2000
Gianfranco Moh'd Suleiman, Jacques Pesce, S. G. Bernier, Chnstos Christodoulou, Dimitnos Bafaloukos, Pans Kosmidis, E. Samantas, Aristotle Bamias, Pavlos Papakostas, A. Karabelis, C. Bacoyiannis, Dimosthenis Skarlos, Lesley Seymour, Hal Hirte, S. Stafford, Greg G. Goss, Wilson H. Miller, Hal Belfer, Gerald Batist, Patricia Hanna', Sarah Matthews, Steven D. Averbuch, Hilary Calvert, Cristiana Sessa, James Carmichael, Paula Calvert, Massimo Zucchetti, Silvia Marsoni, Sabine Van Den Bosch, Angela Robinson, Elena Verdi, Gabnella Camboni, Míguel Ángel, Molina Jordi Codony-Servat, Federico Rojo, Jose María Arribas, Joan Albanell, Evanqelos Briasoulis, D. Rammou, Elefthena Tzamakou, Vasilios Karavasilis, Anatoli Loannidou, Kalliopi Soulti, Nicholas Pavlidis, Carmen Muñoz, Marisa Munoz, Carmen Balafia, José Pontón, Margarita García, Angeles Llorens, Mercedes Gimeno, Rafael Rosell, Jose Germa, Miguel Izquierdo   +53 more
openalex   +1 more source

New Perspectives on Semiconducting Conjugated Oligomers for Neuromodulation in Hydra vulgaris

Advanced Materials Interfaces, EarlyView.
Semiconducting organic compounds, thiophene‐based, modify the rhythmic electrical activity of the cnidarian Hydra vulgaris acting on specific neuronal circuits. The ETE‐S trimer also forms electronically conducting wires in the living tissues of the animal.
Giuseppina Tommasini, Mariarosaria De Simone, Martina Blasio, Claudia Zenna, Angela Tino, Eleni Stavrinidou, Silvia Santillo, Claudia Tortiglione   +7 more
wiley   +1 more source

Alcohol exhibits contrasting effects on CD8⁺ T cells in the gut and liver in alcohol-associated liver disease. [PDF]

Gut
Niu M, Ding WX.
europepmc   +1 more source

The Pharmacology and Therapeutics of Curare and its Constituents [PDF]

Proceedings of the Royal Society of Medicine, 1935
openaire   +3 more sources

Computational and Experimental Analysis of Drug‐Coated Microneedle Skin Insertion: The Mode of Administration Matters

Advanced Materials Interfaces, EarlyView.
This study investigates how the mode of application affects drug delivery from coated microneedles. Combining finite element modeling with custom 3D‐printed Franz Diffusion Cells, the researchers found that prolonged application pressure from microneedles in situ reduces drug permeation.
Wenting Shu, Thomas Lijnse, Fiona McCartney, David J. Brayden, Aisling Ní Annaidh, Eoin D. O'Cearbhaill   +5 more
wiley   +1 more source

Bioengineered Models of Nerve Regeneration

Advanced Materials Technologies, EarlyView.
Bioengineered nerve regeneration platforms ranging from patterned cell cultures and hydrogels to fibrous scaffolds and microfluidic systems are reviewed, highlighting the complex cellular and biochemical environments essential for nerve repair. Challenges associated with these platforms, such as balancing complexity with throughput and the need for ...
Madalynn Jade Thompson, John Paul Frampton   +1 more
wiley   +1 more source

RNA Therapeutics: Focus on Antisense Oligonucleotides in the Nervous System. [PDF]

Biomol Ther (Seoul)
Ertural B, Çiçek BN, Kurnaz IA.
europepmc   +1 more source

The BPS web site for Continuing Professional Development in Clinical Pharmacology and Therapeutics

, 2003
J C Mucklow, Nigel S. Baber, Simon Maxwell, Munir Pirmohamed   +3 more
openalex   +2 more sources

Microfluidic Platform with Local Oxygen Sensors Demonstrates That 3D Blood Vessel Networks Exhibit Time‐Dependent Changes in Oxygen Concentrations During Their Formation and Perfusion

Advanced Materials Technologies, EarlyView.
Novel OoC platform with functional vascular networks highlights challenges in oxygenation. This study uses optical oxygen sensors to monitor oxygen during vascular formation, revealing perfusion limitations and highlighting the need for better oxygenation strategies.
Tarek Gensheimer, Stefanie Fuchs, Laura E. de Heus, Kim Vermeul, Torsten Mayr, Andries v.d. Meer   +5 more
wiley   +1 more source