Results 271 to 280 of about 1,429,081 (399)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

A study to learn if nirogacestat works and is safe for adult participants with desmoid tumors: a plain language summary of the DeFi study. [PDF]

Future Oncol
Kasper B, Whiting J, Lawson D, Portnoy M, Schuster K, Baumgarten C, Ratan R, Lim A, Cho S, Kummar S, Gounder M.   +10 more
europepmc   +1 more source

Ocular therapeutics [PDF]

Clinical and Experimental Optometry, 2007
Genevieve Napper, Julie Albietz
openaire   +2 more sources

The roles and applications of extracellular vesicles in cancer

Molecular Oncology, EarlyView.
Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley   +1 more source

Special pathology and therapeutics of the diseases of domestic animals

, 1912
Ferenc Hutyra, J Marek, John R. Mohler, Adolph Eichhorn   +3 more
openalex   +4 more sources

Immune modulation to treat Alzheimer's disease. [PDF]

Mol Neurodegener
Duggan MR, Morgan DG, Price BR, Rajbanshi B, Martin-Peña A, Tansey MG, Walker KA.   +6 more
europepmc   +1 more source

THE THERAPEUTICS OF ASPIRIN AND MESOTAN. [PDF]

, 1905
James Burnet
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Efficacy Remaining at Time of Requested Re-Treatment for Cervical Dystonia: A Potential New Treatment Paradigm with DaxibotulinumtoxinA. [PDF]

Toxins (Basel)
Ellenbogen A, Hauser RA, Patel AT, McAllister P, Gross TM, Kazerooni R, Gallagher CJ, Hollander DA.   +7 more
europepmc   +1 more source

Advances in Medicinal Therapeutics [PDF]

, 1950
H. H. Dale
openalex   +1 more source