Results 281 to 290 of about 1,412,582 (334)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Development of siRNA therapeutics to combat microbial infections: a bibliometric analysis. [PDF]

Front Cell Infect Microbiol
He Y, Yuan Y, Zhou M, Li M, Li L, Li C, Liang X, Liu P, Wang W, Deng Z.   +9 more
europepmc   +1 more source

Modern Therapeutics and Pharmacy.

, 1905
Frederick Hadra
openalex   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Editorial: Vaccines and therapeutics utilizing new adjuvants and potential inhibitors to target emerging infectious diseases. [PDF]

Front Immunol
Kim J, Jobe O, Broadhurst MJ.
europepmc   +1 more source

Novel Application of Electro-Chemistry to Therapeutics. [PDF]

openalex  

Editorial: From bench to clinic: novel vaccines and therapeutics - "success stories". [PDF]

Front Cell Infect Microbiol
Venkatasubramaniam A, Archer NK.
europepmc   +1 more source

Outcomes of immune checkpoint inhibitor rechallenge in advanced urothelial carcinoma: results from a global real-world evidence study. [PDF]

ESMO Open
Maiorano BA, Cigliola A, Tateo V, Mercinelli C, Pastorino GL, Dizman N, Ebrahimi H, Pal SK, Gupta S, Grivas P, Kamat AM, Spiess PE, Agarwal N, Necchi A.   +13 more
europepmc   +1 more source

FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products: Early-Phase Trials Using Innovative Trial Designs and Biomarkers. [PDF]

Clin Cancer Res
Okusanya OO, Patilea-Vrana GI, Sireci A, Iasonos A, Davidson BA, Liu J, Shord SS, LoRusso PM, Yap TA.   +8 more
europepmc   +1 more source

Editorial: Community series in immunotherapy and small molecule inhibitors as combinational cancer therapeutics, volume II. [PDF]

Front Immunol
Khan MWA, Tripathi SK, Rajendrasozhan S.
europepmc   +1 more source