Results 301 to 310 of about 1,594,004 (375)

Allele-specific HLA LOH in solid tumors: distinct patterns by tumor type and potential prognostic relevance. [PDF]

J Immunother Cancer
Sewastianik T, Roy C, Gormally MV, Montesion M, Halvey P, Jindal A, Lam H, Schoenfeld A, Klebanoff CA, Opiteck GJ, Nagorsen D.   +10 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The impact of desmoid tumors: insights from the Desmoid Tumor Research Foundation Natural History Study, 2017-2023. [PDF]

Orphanet J Rare Dis
Lucas A, Zhou S, Hernandez L, Bell T, Oton AB, Mercier K.   +5 more
europepmc   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

The Pharmacological Basis of Therapeutics: a Textbook of Pharmacology, Toxicology and Therapeutics for Physicians and Medical Students

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openalex   +1 more source

Confirmatory long-term efficacy and safety results of ataluren in patients with nmDMD from Study 041, an international, randomized, double-blind, placebo-controlled, Phase III trial. [PDF]

J Comp Eff Res
Vlodavets D, Wu S, Kostera-Pruszczyk A, Chae JH, Gulati S, Shin JH, Lorentzos M, Cairns A, Jong YJ, Komaki H, Statland J, de Queiroz Campos Araujo AP, Gurgel-Giannetti J, Takeshima Y, Escobar Cedillo RE, Karachunski P, Haginoya K, Penematsa V, Chou C, Williams P, Werner C, McDonald CM.   +21 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Autoantibody profiling to predict response to the anti-PD-1 therapy, pembrolizumab, in rare tumors. [PDF]

ESMO Open
Derbala MH, Hajjar J, Stephen B, Gurses SA, Kwiatkowski E, Budde P, Zucht HD, Bräutigam M, Lindemann AS, Abhari BA, Gouda MA, Castillo L, Zarifa A, How JA, Rodriguez E, Moyers JT, Hong DS, Fu S, Meric-Bernstam F, Naing A.   +19 more
europepmc   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source