Results 321 to 330 of about 1,594,004 (375)

Addressing Challenges in Developing Treatments for Inherited Retinal Diseases: Recommendations From the Third Monaciano Symposium. [PDF]

Transl Vis Sci Technol
Thompson DA, Jayasundera KT, Alekseev O, Ali RR, Amato A, Arshavsky VY, Audo IS, Auricchio A, Bainbridge JWB, Banin E, Besirli CG, Birch DG, Branham KE, Cideciyan AV, Daiger SP, Duncan JL, Fahim AT, Flannery JG, Gattegna R, Heckenlively JR, Héon E, Iannaccone A, Khan NW, Khateb S, Klassen HJ, Leroy BP, Marangoni D, Michaelides M, Musch DC, Pennesi ME, Petersen-Jones SM, Pierce EA, Rao RC, Sahel JA, Sieving PA, Strettoi E, Strong CR, Wubben TJ, Yang P, Zacks DN, Monaciano Consortium.   +40 more
europepmc   +1 more source

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

Inflammation and mutational burden differentially associated with nivolumab or ipilimumab combination efficacy in colorectal cancer. [PDF]

Nat Commun
Lei M, Overman MJ, Yao J, André T, Lonardi S, Lenz HJ, Aglietta M, Gelsomino F, McDermott R, Wong KYM, Morse MA, Van Cutsem E, Hendlisz A, Cardin DB, Neyns B, Hill A, Krishnamurthy A, Chen F, Kochuparambil S, Jenq RR, Abdullaev S, He B, Novosiadly R, Kopetz S.   +23 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

IMPACT OF FARICIMAB VERSUS AFLIBERCEPT ON EPIRETINAL MEMBRANE FORMATION OVER 2 YEARS IN PATIENTS WITH DIABETIC MACULAR EDEMA IN THE PHASE 3 YOSEMITE AND RHINE TRIALS. [PDF]

Retina
Jaffe GJ, Deák G, Gibson K, Khurana RN, Nudleman E, Ogura Y, Schmidt-Erfurth U, Wang T, Westenskow PD, Wong D, Yiu G, Willis JR.   +11 more
europepmc   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Molecular Characterization of NUT Carcinoma: A Report from the NUT Carcinoma Registry. [PDF]

Clin Cancer Res
Kim JJ, Walton SA, Mahadevan NR, Haradon J, Paoloni F, Paik PK, Chaft JE, Hsu R, Piha-Paul SA, Jänne PA, Barbie DA, Sholl LM, DuBois SG, Hanna GJ, Shapiro GI, French CA, Luo J.   +16 more
europepmc   +1 more source

Impact of transplant conditioning, NPM1 mutations, and measurable residual disease in FLT3-ITD acute myeloid leukemia. [PDF]

Blood Adv
Levis MJ, Hamadani M, Logan BR, Jones RJ, Singh AK, Litzow MR, Wingard JR, Papadopoulos EB, Perl AE, Soiffer RJ, Ustun C, Oshima MU, Uy GL, Waller EK, Vasu S, Solh M, Mishra A, Muffly LS, Kim HJ, Stelljes M, Najima Y, Onozawa M, Thomson K, Chen C, Hasabou N, Rosales M, Hill JE, Gill SC, Nuthethi R, King D, Mendizabal A, Devine SM, Horowitz MM, Chen YB.   +33 more
europepmc   +1 more source

Scleritis Secondary to Eosinophilic Granulomatosis With Polyangiitis. [PDF]

J Vitreoretin Dis
Pericak J, Chin EK, Almeida DRP.
europepmc   +1 more source