Results 61 to 70 of about 5,562,093 (291)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Developing cross‐cultural communicative competence via computer‐assisted language learning: The case of pre‐service ESL/EFL teachers [PDF]

, 2001
Based on a qualitative research project, this article presents a view on the use of computer technology to develop a critical cross‐cultural communicative competence in English as a Second Language (ESL) / English as a Foreign Language (EFL) for pre ...
Abdelilah Salim Sehlaoui, Sehlaoui, Abdelilah   +1 more
core   +1 more source

Self-Administered Cognitive Rehabilitation Using an Electronic Device in Subacute Stroke Patients: A Proof-of-Concept Study on Safety, Feasibility, and Preliminary Efficacy

NeuroSci
Background: Cognitive impairment after stroke often reduces independence and quality of life. Cognitive rehabilitation is therefore essential, and recent research on computer-based interventions has shown promising results.
Cristina Fonte, Alessio Damora, Laura Abbruzzese, Giorgia Rotundo, Alessandro Picelli, Ylenia Gallinaro, Elisa Evangelista, Mauro Mancuso, Nicola Smania, Valentina Varalta   +9 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Accuracy and Precision in Computer-Assisted Methods for Orthopaedic Surgery

, 2015
This chapter reviews the major approaches to the definition of bone cutting accuracy in the field of computer-assisted orthopaedic surgery. The first part of the chapter reviews the different concepts of accuracy found in literature, from localization in
Federico E. Milano, Cartiaux, Olivier, Milano, Federico, Olivier Cartiaux   +3 more
core   +1 more source

Feasibility of Vibroacoustic Sensing for Detection of Peritoneal Entry During Laparoscopic Access: A Pilot Study in a Human Body Donor

Diagnostics
Background/Objectives: Establishing laparoscopic access remains a critical and complication-prone step in minimally invasive surgery. Previous work has shown that proximal vibroacoustic sensing can identify peritoneal puncture events in porcine cadavers.
Moritz Spiller, Robin Urrutia, Nazila Esmaeili, Axel Boese, Thomas Neumuth, Alfredo Illanes, Salmai Turial   +6 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A unique style of computer‐assisted assessment [PDF]

, 1998
This paper examines a project at the University of Wolverhampton that has been producing its own unique style of computerized test for several years. The tests are all designed to deliver a different set of questions each time they are run, a fact which ...
Mike Thelwall, Thelwall, Mike
core   +1 more source