Results 221 to 230 of about 2,771,868 (291)

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

Polymicrobial Periprosthetic Infection with <i>Pasteurella canis</i> Following Total Knee Arthroplasty: A Case Report. [PDF]

Reports (MDPI)
Gîrbovan EC, Asztalos AI, Pop AV, Văsieșiu AM, Gîrbovan M, Cighir A.   +5 more
europepmc   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

Rapid Clinical Improvement Temporally Associated with Off-Label LetiFend^® Vaccination in Canine Leishmaniasis: A Case Report. [PDF]

Vaccines (Basel)
Werner T, Rămneanţu M, Naucke TJ.
europepmc   +1 more source

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

Three-Dimensional Planning and Surgical Correction of Bilateral Developmental Valgus Deformity of the Manus in a Dog. [PDF]

Animals (Basel)
Solari FP, Kim MY, Vilaplana Grosso FR, Biedrzycki AH, Lewis DD.   +4 more
europepmc   +1 more source

Case Report: Allogeneic adipose-derived mesenchymal stem cells for severe chronic kidney disease in a dog. [PDF]

Front Vet Sci
Yu Y, Lv X, Zhou X, Ma Y, Li H, Wang W, Song Y.   +6 more
europepmc   +1 more source

Severe Hypernatraemia Secondary to Adipsia Associated With a Pituitary Macroadenoma in a Dog: A Case Report. [PDF]

Vet Med Sci
Choo GB, Choi BK, Choi S, Noh D, An JH.
europepmc   +1 more source

Serum Baclofen Concentrations in Four Dogs With Baclofen Toxicosis Treated With In-Series Carbon Hemoperfusion and Hemodialysis. [PDF]

J Vet Emerg Crit Care (San Antonio)
Spillane A, Her J, Etedali N, Finstad J, Langston C.   +4 more
europepmc   +1 more source