Results 71 to 80 of about 27,700 (262)

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Lack of improvement after short‐term topical antistaphylococcal endolysin SA.100 therapy in patients with mild‐to‐moderate atopic dermatitis: Results from a randomized, vehicle‐controlled trial

British Journal of Clinical Pharmacology, EarlyView.
Abstract Atopic dermatitis (AD) is a chronic immune‐mediated inflammatory skin disease. An overgrowth of Staphylococcus aureus (S. aureus) and decreased microbial diversity is apparent in 70%–90% of AD patients. SA.100 is a recombinant endolysin targeting S. aureus that might be a novel treatment for patients with mild‐to‐moderate AD.
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Ismahaan Abdisalaam, Rianne Rijneveld, Erica S. Klaassen, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Benthe Freyee, Karin Platenkamp, Mariette E. van Poelgeest, Robert Rissmann, Martijn B. A. van Doorn, Tessa Niemeyer – van der Kolk   +15 more
wiley   +1 more source

Leopard in kitten heels: The politics of Theresa May’s sartorial choices [PDF]

Clothing Cultures, 2019
This article discusses the clothing choices of Theresa May as a female Member of Parliament (MP) and as the second woman prime minister of Great Britain. A Conservative MP since 1997 with a conservative background growing up a Vicar’s daughter and grammar school education, Mrs May’s sartorial choices have evolved to conform with an understanding of ...
openaire   +1 more source

S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double‐blind randomized clinical trial in patients with mild to moderate atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this first‐in‐human study was to evaluate the safety, tolerability and efficacy of topical XZ.700 and explore the ...
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Naomi Klarenbeek, Marieke L. de Kam, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Vincent de Jong, Benthe Freyee, Martijn B. A. van Doorn, Robert Rissmann, Tessa Niemeyer–van der Kolk   +13 more
wiley   +1 more source

Lost and found in translation: the value of the human imiquimod model

British Journal of Clinical Pharmacology, EarlyView.
Topical imiquimod (IMQ), a Toll‐like receptor (TLR) 7 agonist, induces transient cutaneous inflammation and is widely used in preclinical research as a ‘psoriasis‐like’ mouse model. However, accumulating evidence indicates substantial divergence between IMQ‐driven biology and human plaque psoriasis pathogenesis.
Anouk C. Meijs, Juliette A. van den Noort, Salma Assil, Naomi B. Klarenbeek, Matthijs Moerland, Tessa Niemeyer‐van der Kolk, Robert Rissmann   +6 more
wiley   +1 more source

Language of Persuasion: Analysis of Conceptual Metaphors in Political Discourse

The Grove, 2021
The aim of this article is to study the scope of conceptual metaphors as a persuasive tool inherent to political discourse in English. In particular, it dwells upon the use of four conceptual metaphors such as NATION IS A FAMILY, STATE IS A BODY ...
Olha Lapka
doaj  

Does education policy affect teachers' learning needs? An international comparison of trends in teachers' continuing professional learning needs in secondary schools in Australia, England, Japan and the Netherlands

British Educational Research Journal, EarlyView.
Abstract Education policy changes are believed to influence teachers' continuing professional learning (CPL) needs, but there is limited empirical evidence to support these claims. This lack of deep understanding has significant practical implications. This study used a new circular conceptual framework to analyse teachers' CPL needs. Leveraging public
Rikkert M. van der Lans, Remmert Daas, Joost Jansen in de Wal, Elaine Wilson, Noriyuki Inoue, Tracy L. Durksen, Frank Cornelissen   +6 more
wiley   +1 more source

Biographies, ontological security and the socio‐spatial politics shaping teachers' mobility in remote Australia

British Educational Research Journal, EarlyView.
Abstract The global teacher shortage continues to intensify, with disparate impacts across geographic and socio‐economic communities. In Queensland, Australia, where this study originates, post‐COVID teacher shortages have intensified workforce pressures, leaving several regional, rural and remote schools as some of the ‘hardest‐to‐staff’ in the ...
Matthew Readette, Reece Mills, Terri Bourke, Simone White, Martin Mills, Lisa van Leent   +5 more
wiley   +1 more source

From Compliance to Circularity: A Design‐Led Approach to Recyclable Packaging

Business Strategy and the Environment, EarlyView.
ABSTRACT The transition to recyclable packaging is a strategic priority for the Fast‐Moving Consumer Goods (FMCG) sector, aligning with the EU Packaging and Packaging Waste Regulation (PPWR). Adapting to regulatory uncertainty and integrating evolving recyclability criteria require not only technical innovation but also organisational transformation ...
Tessa Bronsky, Shahrokh Nikou, Pien Jager   +2 more
wiley   +1 more source

A Look at Brexit by RT, a Russian News Source

Critical Approaches to Discourse Analysis across Disciplines, 2021
This article is a corpus-assisted discourse study of a medium-sized corpus of journalistic content collected from the Russian-language branch of RT, a Russian government-sponsored news source.
Natalia Knoblock
doaj