Results 31 to 40 of about 59,853 (261)

A Fourier Series-Neural Network Based Real-Time Compensation Approach for Geometric and Thermal Errors of CNC Milling Machines

Advances in Mechanical Engineering, 2013
In order to improve the accuracy and efficiency of the real-time error compensation, a Fourier Series-Neural Network (FS-NN) based compensation methodology is developed to reduce the thermally induced geometric errors of CNC milling machines under ...
Wei Wang, Yi Zhang, Kaiguo Fan, Jianguo Yang   +3 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Real-Time Compensation for Thermal Errors of the Milling Machine

Applied Sciences, 2016
This paper is focused on developing a compensation module for reducing the thermal errors of a computer numerical control (CNC) milling machine. The thermal induced displacement variations of machine tools are a vital problem that causes positioning ...
Tsung-Chia Chen, Chia-Jung Chang, Jui-Pin Hung, Rong-Mao Lee, Cheng-Chi Wang   +4 more
doaj   +1 more source

Determination of Core Losses Using an Inverse Modeling Technique

IEEE Access, 2022
This paper presents an inverse thermal modeling technique to determine the core losses from the temperature rise inside the transformer core. For this purpose, initially, a customized printed circuit board (PCB) with thermal sensors is used to measure ...
Osaruyi Osemwinyen, Ahmed Hemeida, Floran Martin, Ismet Tuna Gurbuz, Payam Shams Ghahfarokhi, Anouar Belahcen   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

An Unsupervised Regularization and Dropout based Deep Neural Network and Its Application for Thermal Error Prediction

Applied Sciences, 2020
Due to the large size of the heavy duty machine tool-foundation systems, space temperature difference is high related to thermal error, which affects to system’s accuracy greatly. The recent highly focused deep learning technology could be an alternative
Yang Tian, Guangyuan Pan
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Thermal Error Modeling and Compensation for a Motorized Spindle of a Large CNC Gear Profile Grinding Machine Tool

IEEE Access
To address thermally induced errors in a motorized spindle during the grinding process of a large computer numerical control (CNC) gear profile grinding machine tool, a thermal error modeling method based on the partial least squares (PLS) method was ...
Jie Xie, Chundong Zhou, Haibin Xu
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source